S
Sante Gnerre
Researcher at Illumina
Publications - 13
Citations - 661
Sante Gnerre is an academic researcher from Illumina. The author has contributed to research in topics: Cancer & KRAS. The author has an hindex of 5, co-authored 13 publications receiving 416 citations.
Papers
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Journal ArticleDOI
High-intensity sequencing reveals the sources of plasma circulating cell-free DNA variants.
Pedram Razavi,Bob T. Li,David N Brown,Byoungsok Jung,Earl Hubbell,Ronglai Shen,Wassim Abida,Krishna Juluru,Ino de Bruijn,Chenlu Hou,Oliver Venn,Raymond S. Lim,Aseem Anand,Tara Maddala,Sante Gnerre,Ravi Vijaya Satya,Qinwen Liu,Ling Shen,Nicholas Eattock,Jeanne Yue,Alexander W. Blocker,Mark Lee,Amy J. Sehnert,Hui Xu,Megan P. Hall,Angie Santiago-Zayas,William Novotny,James M. Isbell,Valerie W. Rusch,George Plitas,Alexandra S. Heerdt,Marc Ladanyi,David M. Hyman,David R. Jones,Monica Morrow,Gregory J. Riely,Howard I. Scher,Charles M. Rudin,Mark E. Robson,Luis A. Diaz,David B. Solit,Alex Aravanis,Jorge S. Reis-Filho +42 more
TL;DR: Ultra-sensitive cell-free DNA (cfDNA) sequencing uncovers clonal hematopoiesis as a major source of somatic cfDNA variants in healthy individuals and patients with cancer, and underscores the importance of matched white blood cell DNA sequencing in liquid biopsy procedures.
Journal ArticleDOI
Ultra-deep next-generation sequencing of plasma cell-free DNA in patients with advanced lung cancers: results from the Actionable Genome Consortium.
Bob T. Li,Filip Janku,Byoungsok Jung,Chenlu Hou,Kiran Madwani,Ryan S. Alden,Pedram Razavi,Jorge S. Reis-Filho,Ronglai Shen,James M. Isbell,Alexander W. Blocker,Nicholas Eattock,Sante Gnerre,Ravi Vijaya Satya,H. Xu,Chen Zhao,Megan P. Hall,Yuebi Hu,Amy J. Sehnert,David N Brown,M. Ladanyi,Charles M. Rudin,N. Hunkapiller,Nora Feeney,Gordon B. Mills,Cloud P. Paweletz,Pasi A. Jänne,David B. Solit,G. J. Riely,Alex Aravanis,Geoffrey R. Oxnard +30 more
TL;DR: Ultra-deep plasma NGS with clonal hematopoiesis filtering resulted in de novo detection of targetable oncogenic drivers and resistance mechanisms in patients with NSCLC, including when tissue biopsy was inadequate for genotyping.
Patent
Error suppression in sequenced dna fragments using redundant reads with unique molecular indices (umis)
TL;DR: In this article, the authors present methods, apparatus, systems and computer program products for determining sequences of interest using unique molecular index (UMI) sequences that are uniquely associable with individual polynucleotide fragments, including sequences with low allele frequencies and long sequence length.
Journal ArticleDOI
Development and Validation of an Ultradeep Next-Generation Sequencing Assay for Testing of Plasma Cell-Free DNA from Patients with Advanced Cancer
Filip Janku,Shile Zhang,Jill Waters,Li Liu,Helen J. Huang,Vivek Subbiah,David S. Hong,Daniel D. Karp,Siqing Fu,Xuyu Cai,Nishma M. Ramzanali,Kiran Madwani,Goran Cabrilo,Debra L. Andrews,Yue Zhao,Milind Javle,E. Scott Kopetz,Rajyalakshmi Luthra,Hyunsung John Kim,Sante Gnerre,Ravi Vijaya Satya,Han-Yu Chuang,Kristina M. Kruglyak,Jonathan Toung,Chen Zhao,Richard Shen,John V. Heymach,Funda Meric-Bernstam,Gordon B. Mills,Jian-Bing Fan,Neeraj Salathia +30 more
TL;DR: Ultradeep NGS assay has good sensitivity compared with conventional clinical mutation testing of archival specimens, and a high VAF in mutant cfDNA corresponded with shorter survival.
Journal ArticleDOI
Performance of a high-intensity 508-gene circulating-tumor DNA (ctDNA) assay in patients with metastatic breast, lung, and prostate cancer.
Pedram Razavi,Bob T. Li,Wassim Abida,Alex Aravanis,Byoungsok Jung,Ronglai Shen,Chenlu Hou,Ino de Bruijn,Sante Gnerre,Raymond S. Lim,Dalicia N. Reales,Tara Maddala,Michael F. Berger,Gregory J. Riely,Howard I. Scher,William Novotny,David B. Solit,Mark A Lee,Jorge S. Reis-Filho,José Baselga +19 more
TL;DR: The full, final text of this abstract will be available at abstracts.asco.org at 7:30 AM (EDT) on Saturday, June 3, 2017 and in the Annual Meeting Proceedings online supplement to the June 20, 2017, issue of the Journal of Clinical Oncology.