S
Sara C. B. Buonomo
Researcher at University of Edinburgh
Publications - 4
Citations - 198
Sara C. B. Buonomo is an academic researcher from University of Edinburgh. The author has contributed to research in topics: Replication timing & XIST. The author has an hindex of 4, co-authored 4 publications receiving 140 citations. Previous affiliations of Sara C. B. Buonomo include European Bioinformatics Institute.
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Journal ArticleDOI
Nuclear Architecture Organized by Rif1 Underpins the Replication-Timing Program
Rossana Foti,Stefano Gnan,Daniela Cornacchia,Vishnu Dileep,Aydan Bulut-Karslioglu,Sarah Diehl,Andreas Buness,Felix A. Klein,Wolfgang Huber,Ewan Johnstone,Remco Loos,Paul Bertone,Paul Bertone,David M. Gilbert,Thomas Manke,Thomas Jenuwein,Sara C. B. Buonomo +16 more
TL;DR: It is shown that in mouse embryonic stem cells, Rif1 coats late-replicating domains and, with Lamin B1, identifies most of the late-Replicating genome.
Journal ArticleDOI
Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction.
Stefano Gnan,Stefano Gnan,Stefano Gnan,Ilya M. Flyamer,Kyle N. Klein,Eleonora Castelli,Eleonora Castelli,Alexander Rapp,Andreas Maiser,Naiming Chen,Patrick Weber,Elin Enervald,Elin Enervald,Elin Enervald,M. Cristina Cardoso,Wendy A. Bickmore,David M. Gilbert,Sara C. B. Buonomo,Sara C. B. Buonomo +18 more
TL;DR: In this article, the authors demonstrate that RIF1 is a molecular hub that co-regulates both replication timing and three-dimensional genome organisation, and identify the molecular bases of the co-dependency of the replication-timing program and nuclear architecture.
Posted ContentDOI
Nuclear organisation and replication timing are coupled through RIF1-PP1 interaction
Stefano Gnan,Stefano Gnan,Stefano Gnan,Ilya M. Flyamer,Kyle N. Klein,Eleonora Castelli,Alexander Rapp,Andreas Maiser,Naiming Chen,Patrick Weber,Elin Enervald,Elin Enervald,M. Cristina Cardoso,Wendy A. Bickmore,David M. Gilbert,Sara C. B. Buonomo,Sara C. B. Buonomo +16 more
TL;DR: RIF1 is a molecular hub that co-regulates both nuclear organisation and replication timing and is identified in RIF1 dual function the molecular bases of the co-dependency of the replication-timing program and nuclear architecture.
Posted ContentDOI
A RIF1 and KAP1-based, double-bookmarking system generates a toggle switch that stabilises the identities of the active and inactive X chromosomes during random X inactivation in mouse
TL;DR: A double-bookmarking system, based on the mutually exclusive relationships of Tsix and RIF1, and KAP1, that coordinates the identification of the active and inactive X chromosomes and initiates a self-sustaining loop that transforms an initially stochastic event into a stably inherited asymmetric X chromosome state.