S
Sara Kohnke
Researcher at University of Cambridge
Publications - 8
Citations - 244
Sara Kohnke is an academic researcher from University of Cambridge. The author has contributed to research in topics: Leptin receptor & Oligodendrocyte. The author has an hindex of 4, co-authored 6 publications receiving 115 citations.
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Journal ArticleDOI
Heterogeneity of hypothalamic pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
Brian Y.H. Lam,Irene Cimino,Joseph Polex-Wolf,Sara Kohnke,Debra Rimmington,Valentine P. Iyemere,Nicholas Heeley,Chiara Cossetti,Reiner Schulte,Luis R. Saraiva,Darren W. Logan,Clemence Blouet,Stephen O'Rahilly,Anthony P. Coll,Giles S.H. Yeo +14 more
TL;DR: The data reveal arcuate POMC neurons to be a highly heterogeneous population, each with distinct cell surface receptor gene expression profiles.
Journal ArticleDOI
Don't seek, don't find: The diagnostic challenge of Wernicke's encephalopathy.
TL;DR: The aim of this review is to summarize the clinical features, diagnosis and treatment of Wernicke’s encephalopathy and to highlight some non-traditional causes, such as after bariatric surgery.
Journal ArticleDOI
Activation of the hypothalamic-pituitary-adrenal axis by exogenous and endogenous GDF15.
Irene Cimino,Hanna Kim,Y. C. Loraine Tung,Kent E Pedersen,Debra Rimmington,John Tadross,Sara Kohnke,Ana Neves-Costa,André Barros,Stephanie Joaquim,Don Bennett,Audrey Melvin,Samuel M. Lockhart,Anthony J. Rostron,Jonathan M. Scott,Hui Liu,Keith Burling,Peter Barker,Menna R. Clatworthy,Menna R. Clatworthy,E-Chiang Lee,A. John Simpson,Giles Sh Yeo,Luis F. Moita,Luis F. Moita,Kendra K. Bence,Sebastian Beck Jørgensen,Anthony P. Coll,Danna M. Breen,Stephen O'Rahilly +29 more
TL;DR: In this paper, a blocking antibody to the GDNF-family receptor α-like receptor completely prevented the corticosterone response to GDF15 administration, and the activation of the HPA axis seen in wild-type mice in response to the administration of genotoxic or endoplasmic reticulum toxins was absent in Gdf15−/− mice.
Posted ContentDOI
Heterogeneity of hypothalamic Pro-opiomelanocortin-expressing neurons revealed by single-cell RNA sequencing
Brian Y.H. Lam,Irene Cimino,Joseph Polex-Wolf,Sara Kohnke,Debra Rimmington,Valentine P. Iyemere,Nicholas Heeley,Chiara Cossetti,Reiner Schulte,Luis R. Saraiva,Darren W. Logan,Clemence Blouet,Stephen O'Rahilly,Anthony P. Coll,Giles S.H. Yeo +14 more
TL;DR: Using single cell RNA sequencing, an atlas of gene expression in murine POMC neurons is generated and reveals arcuate PomC neurons to be a highly heterogeneous population.
Journal ArticleDOI
Nutritional regulation of oligodendrocyte differentiation regulates perineuronal net remodeling in the median eminence.
Sara Kohnke,Sophie Buller,Danae Nuzzaci,Katherine Ridley,Brian Y.H. Lam,Helena Pivonkova,Marie A. Bentsen,Kimberly M. Alonge,Chao Zhao,John Tadross,Staffan Holmqvist,Takahiro Shimizu,Hannah Hathaway,Huiliang Li,Wendy B. Macklin,Michael W. Schwartz,William D. Richardson,Giles S.H. Yeo,Robin J.M. Franklin,Ragnhildur Thóra Káradóttir,David H. Rowitch,David H. Rowitch,Clemence Blouet +22 more
TL;DR: The authors showed that refeeding after an overnight fast rapidly triggers proliferation and differentiation of oligodendrocyte progenitors in the median eminence of the brain, leading to the production of new oligod endrocytes in the ME specifically.