Sara Trabulo

TL;DR: The current knowledge of the mechanisms responsible for the cellular uptake of cell-penetrating peptides, including the S413-PV peptide, are discussed, and the potential of peptide-based formulations to mediate nucleic acid delivery is discussed.

TL;DR: Targeting CD47 efficiently enhanced phagocytosis of a representative set of primary pancreatic cancer (stem) cells and also directly induced their apoptosis in the absence of macrophages during long-term inhibition of CD47 strongly suggest that CD47 inhibition could be a novel adjuvant treatment strategy for PDAC independent of underlying and highly variable driver mutations.

TL;DR: It is demonstrated that metformin selectively ablated pancreatic CSCs as evidenced by diminished expression of pluripotency-associated genes and CSC-associated surface markers, which effectively reduced tumor burden and prevented disease progression in primary cancer tissue xenograft models.

TL;DR: This study demonstrates that via to date unreported effects, chloroquine is an effective adjuvant therapy to chemotherapy, offering more efficient tumor elimination and improved cure rates.

TL;DR: The miR-17-92 cluster is identified as a functionally determining family of miRNAs in CSCs, and the putative potential of developing modulators of this cluster to overcome drug resistance in pancreatic C SCs is highlighted.