Michele Cioffi

TL;DR: EVP proteins can serve as reliable biomarkers for cancer detection and determining cancer type, and a panel of tumor-type-specific EVP proteins in TEs and plasma are defined, which can classify tumors of unknown primary origin.

TL;DR: It is found that human pancreatic beta cells and liver organoids are highly permissive to SARS-CoV-2 infection, further validated using adult primary human islets and adult hepatocyte and cholangiocyte organoids.

TL;DR: It appears reasonable to conclude that there is sufficient evidence now for the existence of cancer stem cells in several epithelial tumors and that these cancers stem cells pose a significant threat via their resistance to standard therapies.

TL;DR: This work identified and characterized an intrinsic autofluorescent phenotype in CSCs of diverse epithelial cancers and used this marker to isolate and characterize these cells.

TL;DR: Targeting CD47 efficiently enhanced phagocytosis of a representative set of primary pancreatic cancer (stem) cells and also directly induced their apoptosis in the absence of macrophages during long-term inhibition of CD47 strongly suggest that CD47 inhibition could be a novel adjuvant treatment strategy for PDAC independent of underlying and highly variable driver mutations.