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Ana L. Cardoso
Researcher at University of Coimbra
Publications - 42
Citations - 2139
Ana L. Cardoso is an academic researcher from University of Coimbra. The author has contributed to research in topics: Gene silencing & Medicine. The author has an hindex of 21, co-authored 33 publications receiving 1754 citations.
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Cell-Penetrating Peptides—Mechanisms of Cellular Uptake and Generation of Delivery Systems
TL;DR: The current knowledge of the mechanisms responsible for the cellular uptake of cell-penetrating peptides, including the S413-PV peptide, are discussed, and the potential of peptide-based formulations to mediate nucleic acid delivery is discussed.
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miR-155 modulates microglia-mediated immune response by down-regulating SOCS-1 and promoting cytokine and nitric oxide production
TL;DR: Results show that miR‐155 has a pro‐inflammatory role in microglia and is necessary for the progression of the immune response through the modulation of SOCS‐1, suggesting that, in a chronic inflammatory context, miR •155 inhibition can have a neuroprotective effect.
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Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Ana L. Cardoso,Adelaide Fernandes,Juan Antonio Aguilar-Pimentel,Martin Hrabé de Angelis,Joana R. Guedes,Maria Alexandra Brito,Saida Ortolano,Giovambattista Pani,Sophia Athanasopoulou,Efstathios S. Gonos,Markus Schosserer,Johannes Grillari,Pärt Peterson,Bilge Guvenc Tuna,Soner Dogan,Angelika Meyer,Ronald van Os,Anne-Ulrike Trendelenburg +17 more
TL;DR: Biomarker panels for frailty would be of high value and better than single markers.
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MiRNA-21 silencing mediated by tumor-targeted nanoparticles combined with sunitinib: A new multimodal gene therapy approach for glioblastoma.
Pedro M. Costa,Ana L. Cardoso,Carlos Custódia,Pedro P. Cunha,Luís Pereira de Almeida,Maria C. Pedroso de Lima +5 more
TL;DR: Results provide evidence that CTX-coupled SNALPs are a reliable and efficient system for systemic delivery of anti-miRNA oligonucleotides and suggest that miRNA modulation by the targeted nanoparticles combined with anti-angiogenic chemotherapy may hold promise as an attractive approach towards GBM treatment.
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Early miR-155 upregulation contributes to neuroinflammation in Alzheimer's disease triple transgenic mouse model
Joana R. Guedes,Carlos Custódia,Ricardo Jorge Silva,Luís Pereira de Almeida,Maria C. Pedroso de Lima,Ana L. Cardoso +5 more
TL;DR: Early miR-155 and c-Jun upregulation in the 3xTg AD mice, as well as in Aβ-activated microglia and astrocytes, are suggested to be contributing to the production of inflammatory mediators such as IL-6 and IFN-β.