C
Christopher M. Walker
Researcher at Nationwide Children's Hospital
Publications - 24
Citations - 1771
Christopher M. Walker is an academic researcher from Nationwide Children's Hospital. The author has contributed to research in topics: Hepatitis C virus & Duchenne muscular dystrophy. The author has an hindex of 14, co-authored 24 publications receiving 1597 citations. Previous affiliations of Christopher M. Walker include The Research Institute at Nationwide Children's Hospital & Boston Children's Hospital.
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Journal ArticleDOI
Eteplirsen for the treatment of Duchenne muscular dystrophy
Jerry R. Mendell,Louise R. Rodino-Klapac,Zarife Sahenk,Kandice Roush,Loren Bird,Linda Lowes,Lindsay N. Alfano,Ann Maria Gomez,Sarah Lewis,Janaiah Kota,Vinod Malik,Kim Shontz,Christopher M. Walker,Kevin M. Flanigan,Marco Corridore,John R. Kean,Hugh D. Allen,Chris Shilling,Kathleen R. Melia,Peter Sazani,Jay B. Saoud,Edward M. Kaye +21 more
TL;DR: The authors used a double-blind placebo controlled protocol to test eteplirsen's ability to induce dystrophin production and improve distance walked on the 6-minute walk test (6MWT).
Journal ArticleDOI
Gentamicin-induced readthrough of stop codons in Duchenne muscular dystrophy.
Vinod Malik,Louise R. Rodino-Klapac,Laurence Viollet,Cheryl Wall,Wendy King,Roula al-Dahhak,Sarah Lewis,Christopher Shilling,Janaiah Kota,Carmen Serrano-Munuera,John R. Hayes,John D. Mahan,Katherine J. Campbell,Brenda Banwell,Majed Dasouki,Victoria Watts,Kumaraswamy Sivakumar,Ricardo Bien-Willner,Kevin M. Flanigan,Zarife Sahenk,Richard J. Barohn,Christopher M. Walker,Jerry R. Mendell +22 more
TL;DR: Mutation suppression of stop codons, successfully achieved in the mdx mouse using gentamicin, represents an important evolving treatment strategy in Duchenne muscular dystrophy (DMD).
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Novel Infectious cDNA Clones of Hepatitis C Virus Genotype 3a (Strain S52) and 4a (Strain ED43): Genetic Analyses and In Vivo Pathogenesis Studies
Judith M. Gottwein,Troels K. H. Scheel,Benoit Callendret,Yi-Ping Li,Heather B. Eccleston,Ronald E. Engle,Sugantha Govindarajan,William C. Satterfield,Robert H. Purcell,Christopher M. Walker,Jens Bukh,Jens Bukh +11 more
TL;DR: Genomic consensus sequences recovered from serum at the times of peak viral titers were identical to the sequences of the parental plasmids, and fully functional infectious cDNA clones of HCV genotypes 3a and 4a were generated.
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Acute hepatitis A virus infection is associated with a limited type I interferon response and persistence of intrahepatic viral RNA
Robert E. Lanford,Zongdi Feng,Deborah Chavez,Bernadette Guerra,Kathleen M. Brasky,Yan Zhou,Daisuke Yamane,Alan S. Perelson,Christopher M. Walker,Stanley M. Lemon +9 more
TL;DR: Analysis of HAV infections in three chimpanzees indicates that HAV is far stealthier than HCV early in the course of acute resolving infection, revealing dramatic differences in the kinetics of clearance in the three compartments.
Journal ArticleDOI
Gene therapy for muscular dystrophy: lessons learned and path forward.
Jerry R. Mendell,Louise R. Rodino-Klapac,Zarife Sahenk,Vinod Malik,Brian K. Kaspar,Christopher M. Walker,K. Reed Clark +6 more
TL;DR: A gene therapy approach using a mini-dystrophin transferred in adeno-associated virus (AAV) and suppression of stop codons to promote readthrough of the DMD gene to increase the size and strength of the muscle is completed.