S
Sarah M. Clark
Researcher at University of Maryland, Baltimore
Publications - 24
Citations - 711
Sarah M. Clark is an academic researcher from University of Maryland, Baltimore. The author has contributed to research in topics: Hippocampal formation & Kynurenine pathway. The author has an hindex of 13, co-authored 24 publications receiving 547 citations. Previous affiliations of Sarah M. Clark include United States Department of Veterans Affairs.
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Journal ArticleDOI
Fluoxetine rescues deficient neurogenesis in hippocampus of the Ts65Dn mouse model for Down syndrome
Sarah M. Clark,Jennifer Schwalbe,Melissa R. Stasko,Paul Yarowsky,Alberto C.S. Costa,Alberto C.S. Costa +5 more
TL;DR: Chronic antidepressant treatment with the serotonin selective reuptake inhibitor, fluoxetine, increased neurogenesis in the Ts65Dn to comparable levels seen in the euploid by augmenting both proliferation and survival of BrdU-labeled cells in the subgranular layer and granule cell layer of the hippocampus, respectively.
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Quantification of Brain Maturation and Growth Patterns in C57BL/6J Mice via Computational Neuroanatomy of Diffusion Tensor Images
Sajjad Baloch,Ragini Verma,Hao Huang,Parmeshwar Khurd,Sarah M. Clark,Paul J. Yarowsky,Paul J. Yarowsky,Ted Abel,Susumu Mori,Christos Davatzikos +9 more
TL;DR: In this paper, diffusion tensor magnetic resonance imaging and computational neuroanatomy are used to quantify postnatal developmental patterns of C57BL/6J mouse brain, and a normative baseline is developed, against which transgenic mice may be compared in genotype-phenotype studies.
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Reduced kynurenine pathway metabolism and cytokine expression in the prefrontal cortex of depressed individuals.
Sarah M. Clark,Ana Pocivavsek,James D. Nicholson,Francesca M. Notarangelo,Patricia Langenberg,Robert P. McMahon,Joel E. Kleinman,Thomas M. Hyde,John W. Stiller,Teodor T. Postolache,Robert Schwarcz,Leonardo H. Tonelli +11 more
TL;DR: Contrary to expectations, the present results indicate that depression, in the absence of medical illness or an overt inflammatory process, is associated with compromised, rather than increased, KP metabolism in the VLPFC.
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Environmental neurotoxin-induced progressive model of parkinsonism in rats
Wei-Bin Shen,Kimberly A. McDowell,Aubrey A. Siebert,Sarah M. Clark,Natalie V. Dugger,Kimberly M. Valentino,Hyder A. Jinnah,Carole Sztalryd,Paul S. Fishman,Christopher A. Shaw,M. Samir Jafri,Paul Yarowsky +11 more
TL;DR: In this article, epidemiologic evidence supports a causal link between the consumption of flour made from the washed seeds of the plant, Cycas micronesica, by the Chamorro population of Guam and the development of Amyotrophic Lateral Sclerosis/Parkinsonism Dementia Complex (ALS/PDC).
Journal ArticleDOI
Hydroxynorketamines: Pharmacology and Potential Therapeutic Applications.
Jaclyn N. Highland,Panos Zanos,Lace M. Riggs,Polymnia Georgiou,Sarah M. Clark,Patrick J. Morris,Ruin Moaddel,Craig J. Thomas,Carlos A. Zarate,Edna F. R. Pereira,Todd D. Gould +10 more
TL;DR: A review of the pharmacokinetics and pharmacodynamics of hydroxynorketamines, as well as their behavioral actions, putative mechanisms of action, and potential therapeutic applications can be found in this paper.