S
Sarah Ryan
Researcher at Biogen Idec
Publications - 15
Citations - 2366
Sarah Ryan is an academic researcher from Biogen Idec. The author has contributed to research in topics: Fibrosis & Integrin. The author has an hindex of 11, co-authored 14 publications receiving 2110 citations. Previous affiliations of Sarah Ryan include Boys Town.
Papers
More filters
Journal ArticleDOI
Fumaric acid esters exert neuroprotective effects in neuroinflammation via activation of the Nrf2 antioxidant pathway
Ralf A. Linker,De-Hyung Lee,Sarah Ryan,Anne M van Dam,Rebecca Conrad,Pradeep Bista,Weike Zeng,Xiaoping Hronowsky,Alex Buko,Sowmya Chollate,Gisa Ellrichmann,Wolfgang Brück,Kate Dawson,Susan Goelz,Stefan Wiese,Robert H. Scannevin,Matvey E. Lukashev,Ralf Gold +17 more
TL;DR: The ability of dimethylfumarate to activate nuclear factor (erythroid-derived 2)-related factor 2 may offer a novel cytoprotective modality that further augments the natural antioxidant responses in multiple sclerosis tissue and is not yet targeted by other multiple sclerosis therapies.
Journal ArticleDOI
Blockade of TGF-β inhibits mammary tumor cell viability, migration, and metastases
Rebecca S. Muraoka,Nancy Dumont,Christoph A. Ritter,Teresa C. Dugger,Dana M. Brantley,Jin Chen,Evangeline Easterly,L. Renee Roebuck,Sarah Ryan,Philip Gotwals,Victor Koteliansky,Carlos L. Arteaga +11 more
TL;DR: Blockade of TGF-β signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas.
Journal ArticleDOI
Fumarates Promote Cytoprotection of Central Nervous System Cells against Oxidative Stress via the Nuclear Factor (Erythroid-Derived 2)-Like 2 Pathway
Robert H. Scannevin,Sowmya Chollate,Mi Young Jung,Melanie N. Shackett,Hiral Patel,Pradeep Bista,Weike Zeng,Sarah Ryan,Masayuki Yamamoto,Matvey E. Lukashev,Kenneth J. Rhodes +10 more
TL;DR: DMF and MMF are cytoprotective for neurons and astrocytes against oxidative stress-induced cellular injury and loss, potentially via up-regulation of an Nrf2-dependent antioxidant response, and these data suggest DMF andMMF may function through improving mitochondrial function.
Journal ArticleDOI
Anti-inflammatory effects of astroglial α7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-κB pathway and activation of the Nrf2 pathway.
TL;DR: The results suggest that activating astroglial α7 nAChRs may have a role in neuroprotection by decreasing inflammation and oxidative stress, and therefore could have therapeutic implication for disease modifying treatments of neurodegenerative diseases.
Journal ArticleDOI
Transforming Growth Factor-Beta-Dependent Events in Vascular Remodeling following Arterial Injury
TL;DR: In conclusion, adventitial fibrosis with abundant collagen matrix deposition but not adventitial cell proliferation is dependent upon endogenous TGF-β activity, and inhibition of T GF-β signaling prevents injury-induced reduction in lumen area by promoting vessel enlargement.