Victor Koteliansky

TL;DR: It is demonstrated that IL-13 is a potent stimulator and activator of TGF-β1 in vivo and that this activation is mediated by a plasmin/serine protease- and MMP-9–dependent and CD44-independent mechanism and that the fibrogenic effects of IL- 13 are mediated, in great extent, by this T GF-β pathway.

TL;DR: Blockade of TGF-β signaling may reduce tumor cell viability and migratory potential and represents a testable therapeutic approach against metastatic carcinomas.

TL;DR: The data indicate that CD40–CD154 signaling is important in late atherosclerotic changes, such as lipid core formation and plaque destabilization.

TL;DR: The studies show that the collagen binding α1β1 integrin, VLA-1, is expressed by the majority of influenza-specific CD8 T cells recovered from nonlymphoid tissues during both the acute and memory phases of the response.

TL;DR: It is reported that either integrin α9β1 or α4β1 can mediate cell adhesion to the EIIIA segment and this interaction is blocked both by epitope-mapped E IIIA antibodies as well as by the respective anti-integrins.