Sarah Short

TL;DR: Using double immunofluorescence and immunoelectron microscopy, it is shown that pro- and antiangiogenic proteins are separated in distinct subpopulations of alpha-granules in platelets and megakaryocytes, which may provide a mechanism by which platelets can locally stimulate or inhibit angiogenesis.

TL;DR: The data indicate a central role for EETs in tumorigenesis, offering a mechanistic link between lipid signaling and cancer and emphasizing the critical importance of considering possible effects of EET-modulating drugs on cancer.

TL;DR: It is hypothesized that dormant tumors undergo a stable genetic reprogramming during their switch to the fast-growing phenotype, and novel dormancy-specific biomarkers such as H2BK and Eph receptor A5 (EphA5) were discovered.

TL;DR: Treatment with TNP-470 or angiostatin for 3 days was sufficient to reduce permeability of tumor blood vessels, delayed-type hypersensitivity, and pulmonary edema induced by IL-2, and suggests that caplostatin can be used in the treatment of cancer and inflammation.

TL;DR: It is demonstrated that expression of one of the most potent angiogenesis inhibitors, thrombospondin-1, is up-regulated in the platelets of tumor-bearing mice, and the production and delivery of the endogenous angiogenic inhibitor thromBospondIn-1 by platelets may be a critical host response to suppress tumor growth through inhibiting tumorAngiogenesis.