S
Sarah Stryeck
Researcher at Medical University of Graz
Publications - 31
Citations - 1856
Sarah Stryeck is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Mitochondrion & Apoptosis. The author has an hindex of 15, co-authored 28 publications receiving 1232 citations. Previous affiliations of Sarah Stryeck include University of Graz & Graz University of Technology.
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Journal ArticleDOI
Targeted Apoptosis of Senescent Cells Restores Tissue Homeostasis in Response to Chemotoxicity and Aging
Marjolein P. Baar,Renata M. C. Brandt,Diana A. Putavet,Julian D.D. Klein,Kasper W.J. Derks,Benjamin Bourgeois,Sarah Stryeck,Yvonne Rijksen,Hester van Willigenburg,Danny A. Feijtel,Ingrid van der Pluijm,Jeroen Essers,Wiggert A. van Cappellen,Wilfred F. J. van IJcken,Adriaan B Houtsmuller,Joris Pothof,Ron W. F. de Bruin,Tobias Madl,Jan H.J. Hoeijmakers,Judith Campisi,Judith Campisi,Peter L.J. de Keizer,Peter L.J. de Keizer +22 more
TL;DR: Treatment targeting of senescent cells is feasible under conditions where loss of health has already occurred, and in doing so tissue homeostasis can effectively be restored.
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Cytosolic Aspartate Availability Determines Cell Survival When Glutamine Is Limiting
H. Furkan Alkan,H. Furkan Alkan,Katharina E. Walter,Alba Luengo,Corina T. Madreiter-Sokolowski,Sarah Stryeck,Allison N. Lau,Wael Al-Zoughbi,Caroline A. Lewis,Craig J. Thomas,Gerald Hoefler,Wolfgang F. Graier,Tobias Madl,Matthew G. Vander Heiden,Matthew G. Vander Heiden,Juliane G. Bogner-Strauss +15 more
TL;DR: In this article, aspartate-glutamate carrier 1 (AGC1) was shown to support cell proliferation and cellular redox homeostasis in lowglutamine environments.
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Novel genetically encoded fluorescent probes enable real-time detection of potassium in vitro and in vivo.
Helmut Bischof,Markus Rehberg,Sarah Stryeck,Katharina Artinger,Emrah Eroglu,Markus Waldeck-Weiermair,Benjamin Gottschalk,Rene Rost,Andras T. Deak,Tobias Niedrist,Nemanja Vujic,Hanna Lindermuth,Ruth Prassl,Brigitte Pelzmann,Klaus Groschner,Dagmar Kratky,Kathrin Eller,Alexander R. Rosenkranz,Tobias Madl,Nikolaus Plesnila,Wolfgang F. Graier,Roland Malli +21 more
TL;DR: K+ plays an important role in physiology and disease, but the lack of high specificity K+ sensors limits the understanding of its spatiotemporal dynamics, so genetically-encoded FRET-based probes able to quantify K+ concentration in body fluids, cells and specific organelles are developed.
Journal ArticleDOI
pH-Lemon, a Fluorescent Protein-Based pH Reporter for Acidic Compartments
Sandra Burgstaller,Helmut Bischof,Thomas Gensch,Sarah Stryeck,Benjamin Gottschalk,Jeta Ramadani-Muja,Emrah Eroglu,Rene Rost,Sabine Balfanz,Arnd Baumann,Markus Waldeck-Weiermair,Jesse C. Hay,Jesse C. Hay,Tobias Madl,Wolfgang F. Graier,Roland Malli +15 more
TL;DR: A novel genetically encoded pH probe is engineered by fusing the pH-stable cyan fluorescent protein (FP) variant, mTurquoise2, to the highly pH-sensitive enhanced yellow fluorescent protein, EYFP, which yielded a ratiometric biosensor—referred to as pH-Lemon—optimized for live imaging of distinct pH conditions within acidic cellular compartments.
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Randomised clinical trial: the effects of a multispecies probiotic vs. placebo on innate immune function, bacterial translocation and gut permeability in patients with cirrhosis.
Angela Horvath,Bettina Leber,B. Schmerboeck,M Tawdrous,Gabriele Zettel,A. Hartl,Tobias Madl,Sarah Stryeck,Dietmar Fuchs,S Lemesch,Philipp Douschan,Elisabeth Krones,Walter Spindelboeck,F Durchschein,Florian Rainer,Gernot Zollner,Rudolf E. Stauber,Peter Fickert,Philipp Stiegler,Vanessa Stadlbauer +19 more
TL;DR: Probiotics may correct intestinal dysbiosis and proinflammatory conditions in patients with liver cirrhosis as well as treat nausea, vomiting and diarrhoea.