S
Sascha Pahernik
Researcher at Heidelberg University
Publications - 200
Citations - 5884
Sascha Pahernik is an academic researcher from Heidelberg University. The author has contributed to research in topics: Renal cell carcinoma & Prostate cancer. The author has an hindex of 37, co-authored 194 publications receiving 5186 citations. Previous affiliations of Sascha Pahernik include University of Mainz & University Hospital Heidelberg.
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Journal ArticleDOI
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.
Khurrum Shahzad,Khurrum Shahzad,Fabian Bock,Fabian Bock,Wei Dong,Hongjie Wang,Hongjie Wang,Stefan Kopf,Shrey Kohli,Moh'd Mohanad Al-Dabet,Satish Ranjan,Juliane Wolter,Christian Wacker,Ronald Biemann,Stoyan Stoyanov,Klaus G. Reymann,Peter Söderkvist,Olaf Groß,Vedat Schwenger,Sascha Pahernik,Peter P. Nawroth,Herman Josef Gröne,Thati Madhusudhan,Berend Isermann +23 more
TL;DR: Mitochondrial reactive oxygen species (ROS) and Nlrp3-inflammasome activation in non-myeloid-derived cells aggravate diabetic nephropathy, and targeting the inflammasomes may be a potential therapeutic approach to diabetic neophropathy.
Journal ArticleDOI
Effect of the surface charge of liposomes on their uptake by angiogenic tumor vessels
Senat Krasnici,A. Werner,Martin E. Eichhorn,Marcus Schmitt-Sody,Sascha Pahernik,Birgitta Sauer,Brita Schulze,Michael Teifel,Uwe Michaelis,Kurt Naujoks,Marc Dellian +10 more
TL;DR: Cationic liposomes exhibited a preferential uptake inAngiogenic tumor vessels and therefore may provide an efficient tool for the selective delivery of diagnostic or therapeutic agents to angiogenic blood vessels of solid tumors.
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A Multicenter Randomized Noninferiority Trial Comparing GreenLight-XPS Laser Vaporization of the Prostate and Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: Two-yr Outcomes of the GOLIATH Study
James Andrew Thomas,Andrea Tubaro,Neil Barber,Frank C H d'Ancona,Gordon Muir,Ulrich Witzsch,Marc-Oliver Grimm,Joan Benejam,Jens-Uwe Stolzenburg,Antony C. P. Riddick,Sascha Pahernik,Herman Roelink,Filip Ameye,Christian Saussine,Franck Bruyère,Wolfgang Loidl,Tim Larner,Nirjan-Kumar Gogoi,Richard Hindley,Rolf Muschter,Andrew C. Thorpe,Nitin Shrotri,Stuart L. Graham,Moritz Hamann,Kurt Miller,Martin Schostak,Carlos Capitán,Helmut H. Knispel,Alexander Bachmann +28 more
TL;DR: Twenty-four-mo follow-up data demonstrated that GL-XPS provides a durable surgical option for the treatment of BPO that exhibits efficacy and safety outcomes similar to TURP.
Journal ArticleDOI
Critical Evaluation of Magnetic Resonance Imaging Targeted, Transrectal Ultrasound Guided Transperineal Fusion Biopsy for Detection of Prostate Cancer
Timur H. Kuru,Timur H. Kuru,Matthias Roethke,Jonas Seidenader,Tobias Simpfendörfer,S. Boxler,Khalid Alammar,Philip Rieker,Valentin Popeneciu,Wilfried Roth,Sascha Pahernik,Heinz Peter Schlemmer,Markus Hohenfellner,Boris Hadaschik +13 more
TL;DR: Since multiparametric magnetic resonance imaging still has some limitations, systematic biopsies should currently not be omitted and the morbidity of the transperineal saturation approach is reasonable and mainly self-limiting.
Journal ArticleDOI
180-W XPS GreenLight Laser Vaporisation Versus Transurethral Resection of the Prostate for the Treatment of Benign Prostatic Obstruction: 6-Month Safety and Efficacy Results of a European Multicentre Randomised Trial—The GOLIATH Study
Alexander Bachmann,Andrea Tubaro,Neil Barber,Frank C H d'Ancona,Gordon Muir,Ulrich Witzsch,Marc-Oliver Grimm,Joan Benejam,Jens-Uwe Stolzenburg,Antony C. P. Riddick,Sascha Pahernik,Herman Roelink,Filip Ameye,Christian Saussine,Franck Bruyère,Wolfgang Loidl,Tim Larner,Nirjan-Kumar Gogoi,Richard Hindley,Rolf Muschter,Andrew C. Thorpe,Nitin Shrotri,Stuart Graham,Moritz Hamann,Kurt Miller,Martin Schostak,Carlos Capitán,Helmut H. Knispel,J. Andrew Thomas +28 more
TL;DR: XPS was shown to be noninferior (comparable) to TURP in terms of IPSS, Qmax, and proportion of patients free of complications and PV and PVR were comparable between groups.