S
Shrey Kohli
Researcher at Otto-von-Guericke University Magdeburg
Publications - 42
Citations - 1597
Shrey Kohli is an academic researcher from Otto-von-Guericke University Magdeburg. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 16, co-authored 29 publications receiving 1168 citations. Previous affiliations of Shrey Kohli include Jaypee Institute of Information Technology.
Papers
More filters
Journal ArticleDOI
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic nephropathy.
Khurrum Shahzad,Khurrum Shahzad,Fabian Bock,Fabian Bock,Wei Dong,Hongjie Wang,Hongjie Wang,Stefan Kopf,Shrey Kohli,Moh'd Mohanad Al-Dabet,Satish Ranjan,Juliane Wolter,Christian Wacker,Ronald Biemann,Stoyan Stoyanov,Klaus G. Reymann,Peter Söderkvist,Olaf Groß,Vedat Schwenger,Sascha Pahernik,Peter P. Nawroth,Herman Josef Gröne,Thati Madhusudhan,Berend Isermann +23 more
TL;DR: Mitochondrial reactive oxygen species (ROS) and Nlrp3-inflammasome activation in non-myeloid-derived cells aggravate diabetic nephropathy, and targeting the inflammasomes may be a potential therapeutic approach to diabetic neophropathy.
Nlrp3-inflammasome activation in non-myeloid-derived cells aggravates diabetic
Fabian Bock,Wei Dong,Hongjie Wang,Stefan Kopf,Shrey Kohli,Satish Ranjan,Juliane Wolter,Christian Wacker,Ronald Biemann,Stoyan Stoyanov,Klaus G. Reymann,Olaf Gro,Vedat Schwenger,Sascha Pahernik,Peter P. Nawroth,Thati Madhusudhan,Berend Isermann +16 more
TL;DR: In this paper, an association of diabetic nephropathy with inflammasome activation has been shown, but the pathophysiological relevance of this finding remains unknown, and specific therapies targeting sterile inflammation in diabetic neephropathy are lacking.
Journal ArticleDOI
Defective podocyte insulin signalling through p85-XBP1 promotes ATF6-dependent maladaptive ER-stress response in diabetic nephropathy
Thati Madhusudhan,Hongjie Wang,Wei Dong,Sanchita Ghosh,Fabian Bock,Veera Raghavan Thangapandi,Satish Ranjan,Juliane Wolter,Shrey Kohli,Khurrum Shahzad,Florian H. Heidel,Martin Krueger,Vedat Schwenger,Marcus J. Moeller,Thomas Kalinski,Jochen Reiser,Triantafyllos Chavakis,Berend Isermann +17 more
TL;DR: It is shown that nuclear translocation of the transcription factor spliced X-box binding protein-1 (sXBP1) is selectively impaired in DN, inducing activating transcription factor-6 (ATF6) and C/EBP homology protein (CHOP).
Journal ArticleDOI
Maternal extracellular vesicles and platelets promote preeclampsia via inflammasome activation in trophoblasts
Shrey Kohli,Satish Ranjan,Juliane Hoffmann,Muhammed Kashif,Evelyn A. Daniel,Moh'd Mohanad Al-Dabet,Fabian Bock,Sumra Nazir,Hanna Huebner,Peter R. Mertens,Klaus-Dieter Fischer,Ana Claudia Zenclussen,Stefan Offermanns,Anat Aharon,Benjamin Brenner,Khurrum Shahzad,Khurrum Shahzad,Matthias Ruebner,Berend Isermann +18 more
TL;DR: It is strongly suggested that EVs cause placental sterile inflammation and PE through activation of maternal platelets and purinergic inflammasome activation in trophoblast cells, uncovering a novel thromboinflammatory mechanism at the maternal-embryonic interface.
Journal ArticleDOI
Cytoprotective activated protein C averts Nlrp3 inflammasome–induced ischemia-reperfusion injury via mTORC1 inhibition
Sumra Nazir,Ihsan Gadi,Moh'd Mohanad Al-Dabet,Ahmed Elwakiel,Shrey Kohli,Sanchita Ghosh,Jayakumar Manoharan,Satish Ranjan,Fabian Bock,Fabian Bock,Ruediger C. Braun-Dullaeus,Charles T. Esmon,Charles T. Esmon,Tobias B. Huber,Eric Camerer,Chris Dockendorff,John H. Griffin,Berend Isermann,Khurrum Shahzad,Khurrum Shahzad +19 more
TL;DR: In this paper, the impact of activated protein C (aPC) on inflammasome activity in myocardial and renal IRIs was analyzed, and it was shown that Nlrp3 suppression is required for aPC-mediated protection from IRI.