S
Satheesh K Sivasubramani
Researcher at University of Texas Medical Branch
Publications - 5
Citations - 52
Satheesh K Sivasubramani is an academic researcher from University of Texas Medical Branch. The author has contributed to research in topics: Bacillus anthracis & Duck embryo vaccine. The author has an hindex of 4, co-authored 5 publications receiving 38 citations.
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Journal ArticleDOI
A Replication-Defective Human Type 5 Adenovirus-Based Trivalent Vaccine Confers Complete Protection against Plague in Mice and Nonhuman Primates
Jian Sha,Michelle L. Kirtley,Curtis Klages,Tatiana E. Erova,Maxim V. Telepnev,Duraisamy Ponnusamy,Eric C. Fitts,Wallace B. Baze,Satheesh K Sivasubramani,William S Lawrence,Igor Patrikeev,Jennifer E. Peel,Jourdan A. Andersson,Elena V. Kozlova,Bethany L. Tiner,Johnny W. Peterson,David McWilliams,Snehal S. Patel,Eric Rothe,Vladimir L. Motin,Ashok K. Chopra +20 more
TL;DR: This is the first report showing the efficacy of an adenovirus-vectored trivalent vaccine against pneumonic plague in mouse and nonhuman primate (NHP) models.
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Protection against inhalation anthrax by immunization with Salmonella enterica serovar Typhi Ty21a stably producing protective antigen of Bacillus anthracis
B. Kim Lee Sim,Minglin Li,Manuel Osorio,Yun Wu,Tint T. Wai,Johnny W. Peterson,Eric R. James,Sumana Chakravarty,Lixin Gao,Rui Xu,Natasha Kc,Richard E. Stafford,William S Lawrence,Linsey A. Yeager,Jennifer E. Peel,Satheesh K Sivasubramani,Ashok K. Chopra,Svetlana Filippova,Stephen L. Hoffman +18 more
TL;DR: A vaccine candidate for anthrax infection shows promise for improving preparedness for a biological attack, and the team showed that their hybrid vaccine conferred excellent protection in rabbits and a short vaccination regimen, and suggest further studies into its suitability for human vaccine studies.
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A Lethal Aerosol Exposure Model of Nipah Virus Strain Bangladesh in African Green Monkeys.
Abhishek N. Prasad,Krystle N. Agans,Satheesh K Sivasubramani,Joan B. Geisbert,Viktoriya Borisevich,Chad E. Mire,William S Lawrence,Karla A. Fenton,Thomas W. Geisbert +8 more
TL;DR: A small particle aerosol model of NiVB infection in AGMs achieved uniform lethality and disease pathogenesis reflective of that observed in humans.
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Experimental Infection of Syrian Hamsters With Aerosolized Nipah Virus.
Olivier Escaffre,Terence E. Hill,Tetsuro Ikegami,Terry L. Juelich,Jennifer K. Smith,Lihong Zhang,David E Perez,Colm Atkins,Arnold Park,William S Lawrence,Satheesh K Sivasubramani,Jennifer E. Peel,Johnny W. Peterson,Benhur Lee,Alexander N. Freiberg +14 more
TL;DR: Hamsters infected with small-particle aerosolized NiV undergo similar clinical manifestations of the disease as previously described using liquid inoculum, and exhibit histopathological lesions consistent with NiV patient reports, suggesting NiV droplets could play a role in transmission by close contact.
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Teixobactin provides protection against inhalation anthrax in the rabbit model
William S Lawrence,Jennifer E. Peel,Satheesh K Sivasubramani,Wallace B. Baze,Elbert B. Whorton,David W.C. Beasley,Jason E. Comer,Dallas Hughes,Losee L Ling,Johnny W. Peterson +9 more
TL;DR: Results show that teixobactin was protective against inhalation anthrax infection in the rabbit model, and they indicate the potential of teixOBactin as a therapeutic for the disease.