Showing papers by "Scot A. Marsters published in 1998"
TL;DR: Certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL, which was amplified in about half of 35 primary lung and colon tumours studied and DcR3 messenger RNA was expressed in malignant tissue.
Abstract: Fas ligand (FasL) is produced by activated T cells and natural killer cells and it induces apoptosis (programmed cell death) in target cells through the death receptor Fas/Apol/CD95. One important role of FasL and Fas is to mediate immune-cytotoxic killing of cells that are potentially harmful to the organism, such as virus-infected or tumour cells. Here we report the discovery of a soluble decoy receptor, termed decoy receptor 3 (DcR3), that binds to FasL and inhibits FasL-induced apoptosis. The DcR3 gene was amplified in about half of 35 primary lung and colon tumours studied, and DcR3 messenger RNA was expressed in malignant tissue. Thus, certain tumours may escape FasL-dependent immune-cytotoxic attack by expressing a decoy receptor that blocks FasL.
823 citations
TL;DR: A novel relative of TNF that binds to the recently discovered, death-domain-containing receptor called Apo3, which has overlapping signaling functions with TNF, but displays a much wider tissue distribution.
231 citations
Patent•
18 Nov 1998TL;DR: A tumor necrosis factor homolog, identified as DNA19355, is provided in this article, which has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses.
Abstract: A tumor necrosis factor homolog, identified as DNA19355, is provided. DNA19355 polypeptide has apoptotic activity in mammalian cancer cells and may be involved in proinflammatory responses. Nucleic acid molecules encoding DNA19355, chimeric molecules and antibodies to DNA19355 are also provided.
17 citations
Patent•
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TL;DR: A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided in this paper, where nucleic acid molecules encoding Apo3 ligand, chimeric molecules and antibodies to Apo 3 ligand are also provided.
Abstract: A tumor necrosis factor and lymphotoxin homolog having apoptotic activity, identified as Apo-3 Ligand, is provided. Nucleic acid molecules encoding Apo-3 ligand, chimeric molecules and antibodies to Apo-3 Ligand are also provided.
15 citations