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Robert J. Matusik
Researcher at Vanderbilt University Medical Center
Publications - 162
Citations - 11580
Robert J. Matusik is an academic researcher from Vanderbilt University Medical Center. The author has contributed to research in topics: Prostate cancer & Prostate. The author has an hindex of 54, co-authored 158 publications receiving 10950 citations. Previous affiliations of Robert J. Matusik include Monroe Carell Jr. Children's Hospital at Vanderbilt & Tohoku University.
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Journal ArticleDOI
Prostate cancer in a transgenic mouse.
Norman M. Greenberg,Francesco J. DeMayo,Milton J. Finegold,Daniel Medina,Wayne D. Tilley,J O Aspinall,Gerald R. Cunha,A A Donjacour,Robert J. Matusik,Jeffrey M. Rosen +9 more
TL;DR: The establishment of breeding lines of transgenic mice that reproducibly develop prostate cancer provides an animal model system to study the molecular basis of transformation of normal prostatic cells and the factors influencing the progression to metastatic prostate cancer.
Journal ArticleDOI
Myc-driven murine prostate cancer shares molecular features with human prostate tumors.
Katharine Ellwood-Yen,Thomas G. Graeber,John Wongvipat,M. Luisa Iruela-Arispe,JianFeng Zhang,JianFeng Zhang,Robert J. Matusik,George Thomas,Charles L. Sawyers +8 more
TL;DR: To define Myc's functional role, transgenic mice expressing human c-Myc in the mouse prostate are generated and this approach illustrates how genomic technologies can be applied to mouse cancer models to guide evaluation of human tumor databases.
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Prolactin-mediated transcriptional and post-transcriptional control of casein gene expression
TL;DR: The hormonal regulation of casein gene expression appears to be an "all or none" process occurring only at the transcriptional or post-transcriptional levels, but may involve a coordinated response at several levels to permit the efficient expression of specialized differentiated functions.
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Inhibition of nuclear hormone receptor activity by calreticulin
Shoukat Dedhar,Paul S. Rennie,Mary Shago,Chung-Yee Leung Hagesteijn,Huiling Yang,Jorge Filmus,Robert G. Hawley,Nicholas Bruchovsky,Helen Cheng,Robert J. Matusik,Vincent Giguère +10 more
TL;DR: It is shown that the 60K protein (p60), purified on a KLGFFKR–Sepharose affinity matrix, and recombinant calreticulin can inhibit the binding of androgen receptor to its hormone-responsive DNA element in a KXFFKR-sequence-specific manner.
Journal ArticleDOI
Generation of a prostate epithelial cell-specific Cre transgenic mouse model for tissue-specific gene ablation.
Xiantuo Wu,Jian Wu,Jiapeng Huang,William C. Powell,JianFeng Zhang,Robert J. Matusik,Frank Sangiorgi,Robert E. Maxson,Henry M. Sucov,Pradip Roy-Burman +9 more
TL;DR: The results show that the PB-Cre4 mice have high levels of Cre expression and a high penetrance in the prostatic epithelium, and will be a useful resource for genetic-based studies on prostate development and prostatic disease.