Nora Rozengurt

TL;DR: Global assessment of molecular changes caused by homozygous Pten deletion identified key genes known to be relevant to human prostate cancer, including those "signature" genes associated with human cancer metastasis.

TL;DR: It is recommended that investigators use the Bar Harbor Classification system when characterizing new GEM models or when conducting experimental interventions that may alter the phenotype or natural history of lesion progression in existing models.

TL;DR: This study provides a novel mechanism by which the loss of PTEN can functionally control "two" hits in the course of tumor development by concurrently modulating p53 activity.

TL;DR: The expression of bitter taste receptors of the T2R family in the mouse and rat gastrointestinal tract is demonstrated using reverse transcriptase–PCR and DNA sequencing, immunohistochemistry, and Western blotting.

TL;DR: A series of discussions was initiated by a panel of human, veterinary, and experimental pathologists during the Mouse Models of Human Cancers Consortium (NIH/National Cancer Institute) workshop on mouse models of lung cancer, and a new practical classification scheme was recommended that would allow easier comparison between human and mouse lung neoplasms.