S
Scott G. Daniel
Researcher at Children's Hospital of Philadelphia
Publications - 24
Citations - 446
Scott G. Daniel is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 6, co-authored 13 publications receiving 289 citations. Previous affiliations of Scott G. Daniel include University of Arizona.
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Journal ArticleDOI
Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis
Alyssa N. Coyne,Bhavani Bagevalu Siddegowda,Patricia S. Estes,Jeffrey Johannesmeyer,Tina Kovalik,Scott G. Daniel,Antony Pearson,Robert Bowser,Daniela C. Zarnescu +8 more
TL;DR: Evidence is provided that TDP-43 associates with futsch mRNA in a complex and regulates its expression at the neuromuscular junction (NMJ) in Drosophila and that futsch overexpression is neuroprotective by extending life span, reducing TPD-43 aggregation, and suppressing ALS-like locomotor dysfunction as well as NMJ abnormalities linked to microtubule and synaptic stabilization.
Journal ArticleDOI
A Randomized Trial Comparing the Specific Carbohydrate Diet to a Mediterranean Diet in Adults With Crohn's Disease.
James D. Lewis,Robert S. Sandler,Carol Brotherton,Colleen M. Brensinger,Hongzhe Li,Michael D. Kappelman,Scott G. Daniel,Kyle Bittinger,Lindsey Albenberg,John F. Valentine,John S. Hanson,David L. Suskind,David L. Suskind,Andrea Meyer,Charlene Compher,Meenakshi Bewtra,Akriti Saxena,Angela Dobes,Benjamin L Cohen,Benjamin L Cohen,Ann D. Flynn,Monika Fischer,Sumona Saha,Arun Swaminath,Bruce R. Yacyshyn,Ellen Scherl,Sara N. Horst,Jeffrey R. Curtis,Kimberly Braly,Lisa Nessel,Maureen McCauley,Liam McKeever,Hans H Herfarth +32 more
TL;DR: In this article, the authors compared the effectiveness of the Specific Carbohydrate Diet (SCD) to the Mediterranean Diet (MD) as treatment for Crohn's disease (CD) with mild to moderate symptoms.
Journal ArticleDOI
Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis
Patricia S. Estes,Scott G. Daniel,Abigail P. Mccallum,Ashley Boehringer,Alona S. Sukhina,Rebecca A. Zwick,Daniela C. Zarnescu +6 more
TL;DR: A Drosophila model of ALS based on TDP-43 is developed that recapitulates several aspects of pathology, including motor neuron loss, locomotor dysfunction and reduced survival, and suggests that individual T DP-43 alleles utilize distinct molecular mechanisms, which will be important for developing therapeutic strategies.
Journal ArticleDOI
SCFSlimb ubiquitin ligase suppresses condensin II–mediated nuclear reorganization by degrading Cap-H2
Daniel W. Buster,Scott G. Daniel,Huy Q. Nguyen,Huy Q. Nguyen,Sarah L. Windler,Lara C. Skwarek,Maureen Peterson,Maureen Peterson,Meredith A. Roberts,Joy H. Meserve,Tom A. Hartl,Joseph E. Klebba,David Bilder,Giovanni Bosco,Giovanni Bosco,Gregory C. Rogers +15 more
TL;DR: SCFSlimb-mediated down-regulation of the condensin II subunit Cap-H2 is required to maintain proper organization and morphology of the interphase nucleus.
Journal ArticleDOI
Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon Cancer.
TL;DR: Examining functional shifts in the gut microbiome in CRC using integrated -omics approaches to untangle the role of host genotype, inflammation, and microbial ecology finds clear functional differences in the microbiome tied to specific bacterial species emerge from four pathways related to human colon cancer.