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Scott G. Daniel

Researcher at Children's Hospital of Philadelphia

Publications -  24
Citations -  446

Scott G. Daniel is an academic researcher from Children's Hospital of Philadelphia. The author has contributed to research in topics: Microbiome & Medicine. The author has an hindex of 6, co-authored 13 publications receiving 289 citations. Previous affiliations of Scott G. Daniel include University of Arizona.

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Futsch/MAP1B mRNA Is a Translational Target of TDP-43 and Is Neuroprotective in a Drosophila Model of Amyotrophic Lateral Sclerosis

TL;DR: Evidence is provided that TDP-43 associates with futsch mRNA in a complex and regulates its expression at the neuromuscular junction (NMJ) in Drosophila and that futsch overexpression is neuroprotective by extending life span, reducing TPD-43 aggregation, and suppressing ALS-like locomotor dysfunction as well as NMJ abnormalities linked to microtubule and synaptic stabilization.
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Motor neurons and glia exhibit specific individualized responses to TDP-43 expression in a Drosophila model of amyotrophic lateral sclerosis

TL;DR: A Drosophila model of ALS based on TDP-43 is developed that recapitulates several aspects of pathology, including motor neuron loss, locomotor dysfunction and reduced survival, and suggests that individual T DP-43 alleles utilize distinct molecular mechanisms, which will be important for developing therapeutic strategies.
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Functional Changes in the Gut Microbiome Contribute to Transforming Growth Factor β-Deficient Colon Cancer.

TL;DR: Examining functional shifts in the gut microbiome in CRC using integrated -omics approaches to untangle the role of host genotype, inflammation, and microbial ecology finds clear functional differences in the microbiome tied to specific bacterial species emerge from four pathways related to human colon cancer.