S
Sebastiaan J. Hullegie
Researcher at Erasmus University Rotterdam
Publications - 14
Citations - 449
Sebastiaan J. Hullegie is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Hepatitis C & Boceprevir. The author has an hindex of 9, co-authored 14 publications receiving 375 citations. Previous affiliations of Sebastiaan J. Hullegie include Erasmus University Medical Center.
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Journal ArticleDOI
Declining Hepatitis C Virus (HCV) Incidence in Dutch Human Immunodeficiency Virus-Positive Men Who Have Sex With Men After Unrestricted Access to HCV Therapy
Anne Boerekamps,Guido E.L. van den Berk,F. N. Lauw,Eliane M. S. Leyten,Marjo E. E. van Kasteren,Arne van Eeden,Dirk Posthouwer,Mark A. A. Claassen,Anton S M Dofferhoff,D. W. M. Verhagen,Wouter F W Bierman,Kamilla D. Lettinga,Frank P. Kroon,Corine E Delsing,Paul H. P. Groeneveld,Robert Soetekouw,Edgar J G Peters,Sebastiaan J. Hullegie,Stephanie Popping,David A. M. C. van de Vijver,Charles A. Boucher,Joop E. Arends,Bart J. A. Rijnders +22 more
TL;DR: Unrestricted DAA availability in the Netherlands was followed by a 51% decrease in acute HCV infections among HIV-positive MSM, which contradicts a decrease in risk behavior as an alternative explanation.
Journal ArticleDOI
Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study.
Joost W. Vanhommerig,Femke A.E. Lambers,Janke Schinkel,Ronald B. Geskus,Joop E. Arends,Thijs J W van de Laar,F. N. Lauw,Kees Brinkman,Luuk Gras,Bart J. A. Rijnders,Jan van der Meer,Maria Prins,J. T. M. Van Der Meer,Richard Molenkamp,M Mutschelknauss,Hans-Erik Nobel,H. W. Reesink,J Schinkel,M. van der Valk,G.E.L. van den Berk,Kees Brinkman,David Kwa,N van der Meche,A Toonen,D Vos,M van Broekhuizen,F. N. Lauw,J. W. Mulder,J E Arends,A van Kessel,I de Kroon,Andre Boonstra,M.E. van der Ende,Sebastiaan J. Hullegie,B J A Rijnders,T. van Laar,L Gras,C. Smit,F A E Lambers,MH Prins,J W Vanhommerig,W van der Veldt +41 more
TL;DR: Both sexual behavior and biological factors appear to independently increase the risk of HCV acquisition among HIV-infected MSM.
Journal ArticleDOI
Frequencies of Circulating MAIT Cells Are Diminished in Chronic HCV, HIV and HCV/HIV Co-Infection and Do Not Recover during Therapy.
Michelle Spaan,Sebastiaan J. Hullegie,Boris J. B. Beudeker,Kim Kreefft,Gertine W. van Oord,Zwier M. A. Groothuismink,Marjolein van Tilborg,Bart J. A. Rijnders,Robert J. de Knegt,Mark A. A. Claassen,Andre Boonstra +10 more
TL;DR: It is shown that the frequencies of MAIT cells are reduced in blood of patients with CHCV, HIV and in AHCV/HIV co-infection compared to healthy individuals, and the impact of HIV and HCV infection on the numbers and function ofMAIT cells warrant further studies on the effect of viral infections and the antimicrobial function.
Journal ArticleDOI
Early treatment of acute hepatitis C infection is cost-effective in HIV-infected men-who-have-sex-with-men.
Stephanie Popping,Sebastiaan J. Hullegie,Anne Boerekamps,Bart J. A. Rijnders,Robert J. de Knegt,Jürgen K. Rockstroh,Annelies Verbon,Charles A. Boucher,Brooke E Nichols,Brooke E Nichols,David A. M. C. van de Vijver +10 more
TL;DR: Early DAA treatment for HIV-infected MSM is an excellent and sustainable tool to meet the WHO goal of eliminating HCV in 2030.
Journal ArticleDOI
Current knowledge and future perspectives on acute hepatitis C infection
Sebastiaan J. Hullegie,Joop E. Arends,Bart J. A. Rijnders,William L. Irving,Dominique Salmon,Maria Prins,Annemarie M. J. Wensing,Paul Klenerman,Hakan Leblebicioglu,Christoph Boesecke,Juergen K. Rockstroh,Andy I.M. Hoepelman +11 more
TL;DR: An overview of the current knowledge and uncertainties, together with some future perspectives on acute hepatitis C epidemiology, virology, immunology, and treatment, are given.