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Andre Boonstra
Researcher at Erasmus University Rotterdam
Publications - 194
Citations - 10288
Andre Boonstra is an academic researcher from Erasmus University Rotterdam. The author has contributed to research in topics: Hepatitis B virus & Hepatitis B. The author has an hindex of 39, co-authored 164 publications receiving 9183 citations. Previous affiliations of Andre Boonstra include Erasmus University Medical Center & National Institute for Medical Research.
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Journal ArticleDOI
In vitro generation of interleukin 10-producing regulatory CD4(+) T cells is induced by immunosuppressive drugs and inhibited by T helper type 1 (Th1)- and Th2-inducing cytokines.
Franck J. Barrat,Daniel J. Cua,Andre Boonstra,David F. Richards,Chad Crain,Huub F. J. Savelkoul,René de Waal-Malefyt,Robert L. Coffman,Catherine M. Hawrylowicz,Anne O'Garra +9 more
TL;DR: It is shown that a combination of the immunosuppressive drugs, vitamin D3 and Dexamethasone, induced human and mouse naive CD4+ T cells to differentiate in vitro into regulatory T cells, which produced only interleukin (IL)-10, but no IL-5 and interferon (IFN)-γ, and furthermore retained strong proliferative capacity.
Journal ArticleDOI
Mouse type I IFN-producing cells are immature APCs with plasmacytoid morphology.
Carine Asselin-Paturel,Andre Boonstra,Marc Dalod,Isabelle Durand,Nadia Yessaad,Colette Dezutter-Dambuyant,Alain Vicari,Anne O'Garra,Christine A. Biron,Francine Brière,Giorgio Trinchieri +10 more
TL;DR: It is shown that mouse interferon-α–producing cells (mIPCs) are a unique subset of immature antigen-presenting cells (APCs) that secrete IFN-α upon stimulation with viruses and interleukin 12 (IL-12) in response to viruses and CpG oligodeoxynucleotides, but not bacterial products.
Journal ArticleDOI
1alpha,25-Dihydroxyvitamin d3 has a direct effect on naive CD4(+) T cells to enhance the development of Th2 cells.
Andre Boonstra,Franck J. Barrat,Chad Crain,Victoria L. Heath,Huub F. J. Savelkoul,Huub F. J. Savelkoul,Anne O'Garra +6 more
TL;DR: The findings suggest that vitD3 acts directly on Th cells and can, in the absence of APC, enhance the development of a Th2 phenotype and augment the expression of the transcription factors c-maf and GATA-3.
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IL-10-Secreting Regulatory T Cells Do Not Express Foxp3 but Have Comparable Regulatory Function to Naturally Occurring CD4+CD25+ Regulatory T Cells
Pedro L. Vieira,Jillian R. Christensen,Sophie Minaee,Emma J. O’Neill,Franck J. Barrat,Andre Boonstra,Thomas Barthlott,Brigitta Stockinger,David C. Wraith,Anne O'Garra +9 more
TL;DR: Mouse IL-10-TReg obtained using either in vitro or in vivo regimens of antigenic stimulation did not express the CD4+CD25+ TReg-associated transcription factor Foxp3, and despite the absence of Fox p3 expression, homogeneous populations of IL- 10- TReg inhibited the in vitro proliferation of CD4-CD25− T cells with a similar efficiency to that of CD 4+CD 25+ TRega.
Journal ArticleDOI
Flexibility of mouse classical and plasmacytoid-derived dendritic cells in directing T helper type 1 and 2 cell development: Dependency on antigen dose and differential toll-like receptor ligation
Andre Boonstra,Carine Asselin-Paturel,Michel Gilliet,Chad Crain,Giorgio Trinchieri,Yong-Jun Liu,Anne O'Garra +6 more
TL;DR: It is shown that mouse myeloid and plasmacytoid precursor DCs (pDCs) cultured from bone marrow precursors and ex vivo splenic DC subsets can induce the development of both Th1 and Th2 effector cells depending on the dose of antigen.