T
T. van Laar
Researcher at University Medical Center Groningen
Publications - 71
Citations - 1852
T. van Laar is an academic researcher from University Medical Center Groningen. The author has contributed to research in topics: Medicine & Parkinson's disease. The author has an hindex of 19, co-authored 38 publications receiving 1618 citations. Previous affiliations of T. van Laar include Medisch Spectrum Twente & Leiden University.
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Journal ArticleDOI
MDMX: A novel p53-binding protein with some functional properties of MDM2
A. Shvarts,W. T. Steegenga,N. Riteco,T. van Laar,P. Dekker,M. Bazuine,R. C. A. Van Ham,W. van der Houven van Oordt,G. Hateboer,A. J. Van Der Eb,Aart G. Jochemsen +10 more
TL;DR: The isolation of a cDNA encoding a new p53‐associating protein, called MDMX, is reported, which indicates that at least one additional member of the MDM protein family exists which can modulate p53 function.
Journal ArticleDOI
Adenovirus serotype determines association and localization of the large E1B tumor antigen with cellular tumor antigen p53 in transformed cells.
TL;DR: The distribution and stability of the cellular tumor antigen p53 were studied in baby rat kidney cells transformed by region E1 sequences of nononcogenic adenovirus (Ad) type 5 (Ad5) or oncogenic type 12 (Ad12).
Journal ArticleDOI
Levodopa-carbidopa intestinal gel in advanced Parkinson's: Final results of the GLORIA registry.
Angelo Antonini,Werner Poewe,K. Ray Chaudhuri,Robert Jech,Barbara A. Pickut,Zvezdan Pirtošek,József Attila Szász,Francesc Valldeoriola,Christian Winkler,Lars Bergmann,Ashley Yegin,Koray Onuk,David,Per Odin,Ene Amalia,Guy Arnold,Ovidiu Bajenaru,Bruno Bergmans,Kari Anne Bjørnarå,Jeff Blackie,Matthias Bode,Paul Bourgeois,Stephan Bohlhalter,Ioan Buraga,Pierre R. Burkhard,Philippe Busson,Matilde Calopa,Jesper Clausen,Erik H. Danielsen,Luc Defebvre,Valérie Delvaux,Sophie Dethy,Espen Dietrichs,Oriol De Fabregues,Ransmayr Gerhard,Graziano Gusmaroli,Kirsten Hahn,Björn Hauptmann,Tove Henriksen,Jorge Hernández-Vara,Anne Jeanjean,Michaela Kaiserová,Jan Kassubek,Thomas E. Kimber,Spyridon Konitsiotis,Rejko Krüger,Rejko Krüger,Jaime Kulisevsky,Jo Leenders,Christofer Lundqvist,F. Ory Magne,Pietro Marano,Ivan Milanov,Nicola Modugno,Anjum Misbahuddin,Martin Nevrly,Zikos Panayiotis,Kenn Freddy Pedersen,Stephen Wørlich Pedersen,Lacramioara Perju-Dumbrava,M.M. Ponsen,Bogdan Ovidiu Popescu,Michel Rijntjes,Víctor Puente,Christoph Redecker,Christoph Schrader,Mariachiara Sensi,Mihaela Simu,Cleanthe Spanaki,Alexander Storch,Anette Storstein,Volker Tomantschger,Chris van der Linden,T. van Laar,F. Viallet,Tatiana Witjas,Martin Wolz,Maurizio Zibetti,Michel Van Zandijcke +78 more
TL;DR: LCIG treatment led to sustained improvements in motor fluctuations, non-motor symptoms particularly sleep/fatigue, mood/cognition and gastrointestinal domains, as well as quality of life in advanced PD patients over 24 months.
Journal ArticleDOI
Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study.
Joost W. Vanhommerig,Femke A.E. Lambers,Janke Schinkel,Ronald B. Geskus,Joop E. Arends,Thijs J W van de Laar,F. N. Lauw,Kees Brinkman,Luuk Gras,Bart J. A. Rijnders,Jan van der Meer,Maria Prins,J. T. M. Van Der Meer,Richard Molenkamp,M Mutschelknauss,Hans-Erik Nobel,H. W. Reesink,J Schinkel,M. van der Valk,G.E.L. van den Berk,Kees Brinkman,David Kwa,N van der Meche,A Toonen,D Vos,M van Broekhuizen,F. N. Lauw,J. W. Mulder,J E Arends,A van Kessel,I de Kroon,Andre Boonstra,M.E. van der Ende,Sebastiaan J. Hullegie,B J A Rijnders,T. van Laar,L Gras,C. Smit,F A E Lambers,MH Prins,J W Vanhommerig,W van der Veldt +41 more
TL;DR: Both sexual behavior and biological factors appear to independently increase the risk of HCV acquisition among HIV-infected MSM.
Journal ArticleDOI
Adenovirus E1A proteins inhibit activation of transcription by p53.
W. T. Steegenga,T. van Laar,N. Riteco,Angelo Mandarino,A. Shvarts,A. J. Van Der Eb,Aart G. Jochemsen +6 more
TL;DR: It is shown that the adenovirus E1A proteins also can repress the stimulation of transcription by p53, both in transient transfections and in stably transfected cell lines, indicating that E2A can abolish the normal biological function of p53.