Sebastian Aulmann

TL;DR: A subset of lesions currently classified as PEComas harbors TFE3 gene fusions, and distinctive features of these cases include a tendency to young age, the absence of association with tuberous sclerosis, predominant alveolar architecture and epithelioid cytology, minimal immunoreactivity for muscle markers, and strong (3+) T FE3 immunore activity.

TL;DR: Examination of TFE3 expression as well as the underlying genetic alterations in a large, hospital-based series of renal cell carcinomas with long-term follow-up information shows that Xp11 translocation renal cellcar carcinomas are uncommon tumours accounting for <1% of adult renalcell carcinomas and that the diagnosis of Xp 11 translocations renal cell cancer needs to be verified using molecular techniques.

TL;DR: Findings establish CASIMO1 as the first functional microprotein that plays a role in carcinogenesis and is implicated in the cell lipid homeostasis.

TL;DR: Early methylation changes are frequent in the low‐grade pathway of breast cancer and may be useful in the development of differential diagnostic and possibly also prognostic markers.

TL;DR: In this paper, the expression patterns of surface-bound TRAIL receptors and their prognostic clinical value were determined for 311 patients with breast cancer by immunohistochemistry, showing that TRAIL-R1 was more strongly expressed in better differentiated tumours, and correlated positively with surrogate markers of a better prognosis but negatively with the expression of Her2/neu and the proliferation marker Ki67.