Dieter Weichenhan

TL;DR: The flagship paper of the ICGC/TCGA Pan-Cancer Analysis of Whole Genomes Consortium describes the generation of the integrative analyses of 2,658 whole-cancer genomes and their matching normal tissues across 38 tumour types, the structures for international data sharing and standardized analyses, and the main scientific findings from across the consortium studies.

TL;DR: An unexpectedly dynamic pattern of transcript isoform regulation is found, suggesting a critical regulatory role during HSC differentiation, and a cell cycle/DNA repair signature associated with multipotency in MPP2 cells is found.

TL;DR: Data from a validation cohort of > 10,000 patients showed age-dependent androgen receptor levels and a prevalence of SRs affecting androgen-regulated genes, further substantiating the activity of a characteristic "androgen-type" pathomechanism in EO-PCA.

TL;DR: The results of a community-wide benchmarking study comparing the performance of all widely used methods for DNA methylation analysis that are compatible with routine clinical use are described, with amplicon bisulfite sequencing and bisulfITE pyrosequencing showing the best all-round performance.

TL;DR: It is shown that tumors derive largely from a continuum of maturation states reflected in normal developmental stages, and a potential pathogenic role for transcription factor dysregulation in CLL is identified, where excess programming by EGR and NFAT with reduced EBF and AP-1 programming imbalances the normal B cell epigenetic program.