S
Sebastian Rogatti
Researcher at MRC Mitochondrial Biology Unit
Publications - 5
Citations - 2041
Sebastian Rogatti is an academic researcher from MRC Mitochondrial Biology Unit. The author has contributed to research in topics: Mitochondrion & Oxidative stress. The author has an hindex of 5, co-authored 5 publications receiving 1512 citations. Previous affiliations of Sebastian Rogatti include National Institute for Health Research.
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Journal ArticleDOI
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Edward T. Chouchani,Edward T. Chouchani,Victoria R. Pell,Edoardo Gaude,Dunja Aksentijevic,Stephanie Y. Sundier,Ellen L. Robb,Angela Logan,Sergiy M. Nadtochiy,Emily N.J. Ord,Anthony C. Smith,Filmon Eyassu,Rachel Shirley,Chou Hui Hu,Anna J. Dare,Andrew M. James,Sebastian Rogatti,Richard C. Hartley,Simon Eaton,Ana S. H. Costa,Paul S. Brookes,Sean M. Davidson,Michael R. Duchen,Kourosh Saeb-Parsy,Michael J. Shattock,Alan J. Robinson,Lorraine M. Work,Christian Frezza,Thomas Krieg,Michael P. Murphy +29 more
TL;DR: In this article, a comparative in vivo metabolomic analysis was conducted to identify widely conserved metabolic pathways responsible for mitochondrial reactive oxygen species (ROS) production during ischaemia reperfusion.
Journal ArticleDOI
In vivo levels of mitochondrial hydrogen peroxide increase with age in mtDNA mutator mice
Angela Logan,Irina G. Shabalina,Tracy A. Prime,Sebastian Rogatti,Anastasia V. Kalinovich,Richard C. Hartley,Ralph C. Budd,Barbara Cannon,Michael P. Murphy +8 more
TL;DR: The prolonged presence of mtDNA mutations in vivo increases hydrogen peroxide that contributes to an accelerated aging phenotype, perhaps through the activation of pro‐apoptotic and pro‐inflammatory redox signaling pathways.
Journal ArticleDOI
The mitochondria-targeted anti-oxidant MitoQ decreases ischemia-reperfusion injury in a murine syngeneic heart transplant model
Anna J. Dare,Angela Logan,Tracy A. Prime,Sebastian Rogatti,Martin Goddard,Eleanor M. Bolton,J. Andrew Bradley,Gavin J. Pettigrew,Michael P. Murphy,Kourosh Saeb-Parsy +9 more
TL;DR: In this article, the anti-oxidant MitoQ was used to prevent post-transplant ischemia-reperfusion (IR) injury in a murine heterotopic cardiac transplant model.
Journal ArticleDOI
Using exomarkers to assess mitochondrial reactive species in vivo.
Angela Logan,Helena M. Cochemé,Helena M. Cochemé,Pamela Boon Li Pun,Nadezda Apostolova,Robin A.J. Smith,Lesley Larsen,David S. Larsen,Andrew M. James,Ian M. Fearnley,Sebastian Rogatti,Tracy A. Prime,Peter G. Finichiu,Anna J. Dare,Edward T. Chouchani,Victoria R. Pell,Carmen Methner,Caroline Quin,Stephen J. McQuaker,Thomas Krieg,Richard C. Hartley,Michael P. Murphy +21 more
TL;DR: The development of MitoB, a mitochondria-targeted probes that generate exomarkers that can be analysed ex vivo by mass spectrometry to assess levels of reactive species within mitochondria in vivo, is described and expanded on.
Journal ArticleDOI
A mitochondria-targeted mass spectrometry probe to detect glyoxals: implications for diabetes.
Pamela Boon Li Pun,Angela Logan,Victor M. Darley-Usmar,Balu K. Chacko,Michelle S. Johnson,Guang W. Huang,Sebastian Rogatti,Tracy A. Prime,Carmen Methner,Thomas Krieg,Ian M. Fearnley,Lesley Larsen,David S. Larsen,Katja E. Menger,Yvonne Collins,Andrew M. James,G.D. Kishore Kumar,Richard C. Hartley,Robin A.J. Smith,Michael P. Murphy +19 more
TL;DR: It is indicated that the levels of methylglyoxal and glyoxal within mitochondria increase during hyperglycemia both in cells and in vivo, suggesting that they can contribute to the pathological mitochondrial dysfunction that occurs in diabetes and aging.