K
Kourosh Saeb-Parsy
Researcher at University of Cambridge
Publications - 161
Citations - 14230
Kourosh Saeb-Parsy is an academic researcher from University of Cambridge. The author has contributed to research in topics: Transplantation & Biology. The author has an hindex of 38, co-authored 133 publications receiving 8161 citations. Previous affiliations of Kourosh Saeb-Parsy include Hinchingbrooke Hospital & Hillingdon Hospital.
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Journal ArticleDOI
SARS-CoV-2 Receptor ACE2 Is an Interferon-Stimulated Gene in Human Airway Epithelial Cells and Is Detected in Specific Cell Subsets across Tissues.
Carly G. K. Ziegler,Samuel J. Allon,Sarah K. Nyquist,Ian M. Mbano,Vincent N. Miao,Constantine N. Tzouanas,Yuming Cao,Ashraf S. Yousif,Julia Bals,Blake M. Hauser,Blake M. Hauser,Jared Feldman,Jared Feldman,Christoph Muus,Christoph Muus,Marc H. Wadsworth,Samuel W. Kazer,Travis K. Hughes,Benjamin Doran,G. James Gatter,G. James Gatter,G. James Gatter,Marko Vukovic,Faith Taliaferro,Faith Taliaferro,Benjamin E. Mead,Zhiru Guo,Jennifer P. Wang,Delphine Gras,Magali Plaisant,Meshal Ansari,Ilias Angelidis,Heiko Adler,Jennifer M.S. Sucre,Chase J. Taylor,Brian M. Lin,Avinash Waghray,Vanessa Mitsialis,Vanessa Mitsialis,Daniel F. Dwyer,Kathleen M. Buchheit,Joshua A. Boyce,Nora A. Barrett,Tanya M. Laidlaw,Shaina L. Carroll,Lucrezia Colonna,Victor Tkachev,Victor Tkachev,Christopher W. Peterson,Christopher W. Peterson,Alison Yu,Alison Yu,Hengqi Betty Zheng,Hengqi Betty Zheng,Hannah P. Gideon,Caylin G. Winchell,Philana Ling Lin,Philana Ling Lin,Colin D. Bingle,Scott B. Snapper,Scott B. Snapper,Jonathan A. Kropski,Jonathan A. Kropski,Fabian J. Theis,Herbert B. Schiller,Laure-Emmanuelle Zaragosi,Pascal Barbry,Alasdair Leslie,Alasdair Leslie,Hans-Peter Kiem,Hans-Peter Kiem,JoAnne L. Flynn,Sarah M. Fortune,Sarah M. Fortune,Sarah M. Fortune,Bonnie Berger,Robert W. Finberg,Leslie S. Kean,Leslie S. Kean,Manuel Garber,Aaron G. Schmidt,Aaron G. Schmidt,Daniel Lingwood,Alex K. Shalek,Jose Ordovas-Montanes,Nicholas E. Banovich,Alvis Brazma,Tushar J. Desai,Thu Elizabeth Duong,Oliver Eickelberg,Christine S. Falk,Michael Farzan,Ian A. Glass,Muzlifah Haniffa,Peter Horvath,Deborah T. Hung,Naftali Kaminski,Mark A. Krasnow,Malte Kühnemund,Robert Lafyatis,Haeock Lee,Sylvie Leroy,Sten Linnarson,Joakim Lundeberg,Kerstin B. Meyer,Alexander V. Misharin,Martijn C. Nawijn,Marko Nikolic,Dana Pe'er,Joseph E. Powell,Stephen R. Quake,Jay Rajagopal,Purushothama Rao Tata,Emma L. Rawlins,Aviv Regev,Paul A. Reyfman,Mauricio Rojas,Orit Rosen,Kourosh Saeb-Parsy,Christos Samakovlis,Herbert B. Schiller,Joachim L. Schultze,Max A. Seibold,Douglas P. Shepherd,Jason R. Spence,Avrum Spira,Xin Sun,Sarah A. Teichmann,Fabian J. Theis,Alexander M. Tsankov,Maarten van den Berge,Michael von Papen,Jeffrey A. Whitsett,Ramnik J. Xavier,Yan Xu,Kun Zhang +135 more
TL;DR: The data suggest that SARS-CoV-2 could exploit species-specific interferon-driven upregulation of ACE2, a tissue-protective mediator during lung injury, to enhance infection.
Journal ArticleDOI
Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS.
Edward T. Chouchani,Edward T. Chouchani,Victoria R. Pell,Edoardo Gaude,Dunja Aksentijevic,Stephanie Y. Sundier,Ellen L. Robb,Angela Logan,Sergiy M. Nadtochiy,Emily N.J. Ord,Anthony C. Smith,Filmon Eyassu,Rachel Shirley,Chou Hui Hu,Anna J. Dare,Andrew M. James,Sebastian Rogatti,Richard C. Hartley,Simon Eaton,Ana S. H. Costa,Paul S. Brookes,Sean M. Davidson,Michael R. Duchen,Kourosh Saeb-Parsy,Michael J. Shattock,Alan J. Robinson,Lorraine M. Work,Christian Frezza,Thomas Krieg,Michael P. Murphy +29 more
TL;DR: In this article, a comparative in vivo metabolomic analysis was conducted to identify widely conserved metabolic pathways responsible for mitochondrial reactive oxygen species (ROS) production during ischaemia reperfusion.
Journal ArticleDOI
Human primary liver cancer–derived organoid cultures for disease modeling and drug screening
Laura Broutier,Gianmarco Mastrogiovanni,Monique M A Verstegen,Hayley E. Francies,Lena Morrill Gavarró,Charles R. Bradshaw,George E. Allen,Robert Arnes-Benito,Olga Sidorova,Marcia P. Gaspersz,Nikitas Georgakopoulos,Bon-Kyoung Koo,Sabine Dietmann,Susan E. Davies,Raaj K. Praseedom,Ruby Lieshout,Jan N. M. IJzermans,Stephen J. Wigmore,Kourosh Saeb-Parsy,Mathew J. Garnett,Luc J. W. van der Laan,Meritxell Huch +21 more
TL;DR: The wide-ranging biomedical utilities of PLC-derived organoid models in furthering the understanding of liver cancer biology and in developing personalized-medicine approaches for the disease are demonstrated.
Journal ArticleDOI
Somatic mutant clones colonize the human esophagus with age
Inigo Martincorena,Joanna C. Fowler,Agnieszka Wabik,Andrew R. J. Lawson,Federico Abascal,Michael W. J. Hall,Michael W. J. Hall,Alex Cagan,Kasumi Murai,Krishnaa T. Mahbubani,Michael R. Stratton,Rebecca C. Fitzgerald,Penny A. Handford,Peter J. Campbell,Peter J. Campbell,Kourosh Saeb-Parsy,Philip H. Jones +16 more
TL;DR: Targeted gene sequencing of normal esophageal epithelium from nine human donors found strong positive selection of clones carrying mutations in 14 cancer genes, with tens to hundreds of clones per square centimeter in middle-aged and elderly donors.
Journal ArticleDOI
Cells of the adult human heart.
Monika Litviňuková,Monika Litviňuková,Carlos Talavera-López,Carlos Talavera-López,Henrike Maatz,Daniel Reichart,Daniel Reichart,Catherine L. Worth,Eric L. Lindberg,Masatoshi Kanda,Masatoshi Kanda,Krzysztof Polanski,Matthias Heinig,Michael Lee,Emily R. Nadelmann,Kenny Roberts,Liz Tuck,Eirini S. Fasouli,Daniel M. DeLaughter,Barbara McDonough,Barbara McDonough,Barbara McDonough,Hiroko Wakimoto,Joshua M. Gorham,Sara Samari,Krishnaa T. Mahbubani,Kourosh Saeb-Parsy,Giannino Patone,Joseph J. Boyle,Hongbo Zhang,Hongbo Zhang,Hao Zhang,Anissa Viveiros,Gavin Y. Oudit,Omer Ali Bayraktar,Jonathan G. Seidman,Christine E. Seidman,Christine E. Seidman,Christine E. Seidman,Michela Noseda,Michela Noseda,Norbert Hubner,Sarah A. Teichmann,Sarah A. Teichmann +43 more
TL;DR: The state-of-the-art analyses of large-scale single-cell and single-nucleus transcriptomes are used to construct a cellular atlas of the human heart that will aid further research into cardiac physiology and disease and provides a valuable reference for future studies.