S
Sergio Bacallado
Researcher at University of Cambridge
Publications - 33
Citations - 1747
Sergio Bacallado is an academic researcher from University of Cambridge. The author has contributed to research in topics: Bayesian probability & Markov chain. The author has an hindex of 11, co-authored 30 publications receiving 1572 citations. Previous affiliations of Sergio Bacallado include Massachusetts Institute of Technology & Stanford University.
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Journal ArticleDOI
A combinatorial library of lipid-like materials for delivery of RNAi therapeutics
Akin Akinc,Andreas Zumbuehl,Andreas Zumbuehl,Michael S. Goldberg,Elizaveta S. Leshchiner,Valentina Busini,Naushad Hossain,Sergio Bacallado,David N. Nguyen,Jason Fuller,Rene Alvarez,Anna Borodovsky,Todd Borland,Rainer Constien,Antonin de Fougerolles,J. Robert Dorkin,K. Narayanannair Jayaprakash,Muthusamy Jayaraman,Matthias John,Victor Koteliansky,Muthiah Manoharan,Lubomir Nechev,June Qin,Timothy Racie,Denitza Raitcheva,Kallanthottathil G. Rajeev,Dinah W.Y. Sah,Jürgen Soutschek,Ivanka Toudjarska,Hans-Peter Vornlocher,Tracy Zimmermann,Robert Langer,Daniel G. Anderson +32 more
TL;DR: A new class of lipid-like delivery molecules, termed lipidoids, are described, that facilitate high levels of specific silencing of endogenous gene transcripts when formulated with either double-stranded small interfering RNA (siRNA) or single-Stranded antisense 2′-O-methyl (2′-OMe) oligoribonucleotides targeting microRNA (miRNA).
Journal ArticleDOI
Rapid equilibrium sampling initiated from nonequilibrium data
TL;DR: The adaptive seeding method (ASM), which uses nonequilibrium GE simulations to identify the metastable states, and seeds short simulations at constant temperature from each of them to quantitatively determine their equilibrium populations, and is well suited to running on modern computer clusters.
Journal ArticleDOI
Deterministic matrices matching the compressed sensing phase transitions of Gaussian random matrices
Hatef Monajemi,Sina Jafarpour,Matan Gavish,Stat,David L. Donoho,Sivaram Ambikasaran,Sergio Bacallado,Dinesh Bharadia,Yuxin Chen,Young Ki Choi,Mainak Chowdhury,Soham Chowdhury,Anil Damle,Will Fithian,Georges Goetz,Logan Grosenick,Samuel R. Gross,Gage Hills,Michael Hornstein,Milinda Lakkam,Jason D. Lee,Jian Li,Linxi Liu,Carlos Sing-Long,Michael Marx,Akshay Mittal,Albert No,Reza Omrani,Leonid Pekelis,Junjie Qin,Kevin S. Raines,Ernest K. Ryu,Andrew M. Saxe,Dai Shi,Keith Siilats,David Strauss,Gary Tang,Chaojun Wang,Zoey Zhou,Zhen Zhu +39 more
TL;DR: It is observed that convex optimization is successful over a region of the phase diagram that coincides with the region known for Gaussian random matrices, and this finding is established for each of the four associated phase transitions.
Journal ArticleDOI
Bayesian comparison of Markov models of molecular dynamics with detailed balance constraint
TL;DR: A Bayesian approach is proposed, which makes it possible to differentiate between models at a fixed lag time making use of short trajectories, and applies a conjugate prior for reversible Markov chains.
Journal ArticleDOI
Persistent Topology and Metastable State in Conformational Dynamics
TL;DR: A data-exploratory tool which provides an overview of the clustering structure under different parameters and provides a systematic way to discover clusters that are robust to perturbations of the data.