S
Seth M. Cohen
Researcher at University of California, San Diego
Publications - 511
Citations - 39017
Seth M. Cohen is an academic researcher from University of California, San Diego. The author has contributed to research in topics: Neutrino & Medicine. The author has an hindex of 91, co-authored 476 publications receiving 33642 citations. Previous affiliations of Seth M. Cohen include Massachusetts Institute of Technology & École Polytechnique Fédérale de Lausanne.
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Fragment-Based Identification of Influenza Endonuclease Inhibitors.
TL;DR: The development of inhibitors of influenza PA endonuclease derived from lead compounds identified from a metal-binding pharmacophore (MBP) library screen were reported, finding Pyromeconic acid and derivatives thereof were found to be potent inhibitors of end onuclease.
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Model Complexes of Cobalt-Substituted Matrix Metalloproteinases: Tools for Inhibitor Design
TL;DR: The findings presented here suggest that [(Tp(Ph,Me)Co(L)] complexes can be used as spectroscopic references for investigating the mode of inhibitor binding in metalloproteinases of medicinal interest.
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Flux melting of metal–organic frameworks
Louis Longley,Sean M. Collins,Shichun Li,Shichun Li,Glen J. Smales,Ilknur Erucar,Ang Qiao,Jingwei Hou,Cara M. Doherty,Aaron W. Thornton,Anita J. Hill,Xiao Yu,Nicholas J. Terrill,Andrew J. Smith,Seth M. Cohen,Paul A. Midgley,David A. Keen,Shane G. Telfer,Thomas D. Bennett +18 more
TL;DR: Flux melting is shown by using a liquid MOF as a solvent for a secondary, non-melting MOF component.
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DNA-binding and oligomerization studies of the manganese(II) metalloregulatory protein MntR from Bacillus subtilis.
TL;DR: The data here demonstrate that differences in metal-activated DNA binding plays a role in the mechanism of manganese(II)-selective transcription factors and that the oligomerization of MntR is metal-independent, which distinguishes this protein from iron(II-responsive homologues in the DtxR protein family.
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Dipyrromethene complexes of iron
Seth M. Cohen,Sara R. Halper +1 more
TL;DR: In this paper, the synthesis, structure, spectroscopy, and electrochemistry of two dipyrrin iron(III) complexes were reported, which represent the first structures of iron-dipyrrin complexes, as well as the first electrochemical studies of any meso-substituted dipyrin transition metal complexes.