S
Seunghee Lee
Researcher at Pohang University of Science and Technology
Publications - 48
Citations - 3884
Seunghee Lee is an academic researcher from Pohang University of Science and Technology. The author has contributed to research in topics: Transcription factor & Coactivator. The author has an hindex of 28, co-authored 47 publications receiving 3464 citations. Previous affiliations of Seunghee Lee include Oregon Health & Science University & Seoul National University.
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Journal ArticleDOI
Regulation of MLL1 H3K4 methyltransferase activity by its core components
Yali Dou,Thomas A. Milne,Alexander J. Ruthenburg,Alexander J. Ruthenburg,Seunghee Lee,Jae Woon Lee,Gregory L. Verdine,C. David Allis,Robert G. Roeder +8 more
TL;DR: This study reports the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex and demonstrates that WDR5 mediates interactions of the MLL1 catalytic unit both with the common structural platform and with the histone substrate.
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The microRNA miR-124 antagonizes the anti-neural REST/SCP1 pathway during embryonic CNS development.
TL;DR: The results suggest that, during CNS development, timely down-regulation of SCP1 is critical for inducing neurogenesis, and miR-124 contributes to this process at least in part by down-regulating SCP1 expression.
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Flexible Near-Field Wireless Optoelectronics as Subdermal Implants for Broad Applications in Optogenetics
Gunchul Shin,Adrian M. Gomez,Ream Al-Hasani,Yu Ra Jeong,Jeonghyun Kim,Zhaoqian Xie,Zhaoqian Xie,Anthony Banks,Seungmin Lee,Sang Youn Han,Sang Youn Han,Chul Jong Yoo,Jong-Lam Lee,Seunghee Lee,Jonas Kurniawan,Jacob Tureb,Zhongzhu Guo,Jangyeol Yoon,Sung Il Park,Sang Yun Bang,Yoonho Nam,Marie C. Walicki,Vijay K. Samineni,Aaron D. Mickle,Kunhyuk Lee,Seung Yun Heo,Jordan G. McCall,Taisong Pan,Liang Wang,Xue Feng,Tae Il Kim,Jong Kyu Kim,Yuhang Li,Yonggang Huang,Robert W. Gereau,Jeong Sook Ha,Michael R. Bruchas,John A. Rogers +37 more
TL;DR: A simple but powerful setup based on wireless, near-field power transfer and miniaturized, thin, flexible optoelectronic implants, for complete optical control in a variety of behavioral paradigms, with broad potential for optogenetics applications is presented.
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A tumor suppressive coactivator complex of p53 containing ASC-2 and histone H3-lysine-4 methyltransferase MLL3 or its paralogue MLL4
Jeongkyung Lee,Dae-Hwan Kim,Seunghee Lee,Qi-Heng Yang,Dong Kee Lee,Soo-Kyung Lee,Robert G. Roeder,Jae Woon Lee +7 more
TL;DR: This study identifies a specific H3K4 methytransferase complex, ASCOM, as a physiologically relevant coactivator for p53 and implicates ASCOM in the p53 tumor suppression pathway in vivo.
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cAMP/PKA signalling reinforces the LATS–YAP pathway to fully suppress YAP in response to actin cytoskeletal changes
Minchul Kim,Miju Kim,Seunghee Lee,Seunghee Lee,Shinji Kuninaka,Hideyuki Saya,Ho Lee,Soo Kyung Lee,Dae-Sik Lim +8 more
TL;DR: It is shown that cyclic AMP (cAMP)‐dependent protein kinase (PKA) phosphorylates LATS and thereby enhances its activity sufficiently to phosphorylate YAP on Ser381, and PKA activity is involved in all contexts previously reported to trigger the LATS–YAP pathway, including actin cytoskeletal damage.