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Alexander J. Ruthenburg

Researcher at University of Chicago

Publications -  42
Citations -  6391

Alexander J. Ruthenburg is an academic researcher from University of Chicago. The author has contributed to research in topics: Chromatin & Histone. The author has an hindex of 20, co-authored 37 publications receiving 5843 citations. Previous affiliations of Alexander J. Ruthenburg include Harvard University & Rockefeller University.

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Journal ArticleDOI

How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers

Sean D. Taverna, +4 more
- 01 Nov 2007 - 
TL;DR: Key features in molecular recognition of histone PTMs by a diverse family of 'reader pockets', highlighting specific readout mechanisms for individual marks, common themes and insights into the downstream functional consequences of the interactions are summarized.
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Methylation of Lysine 4 on Histone H3: Intricacy of Writing and Reading a Single Epigenetic Mark

Alexander J. Ruthenburg, +2 more
- 12 Jan 2007 - 
TL;DR: It is hypothesize how the unique properties of the polyvalent chromatin fiber and associated effectors may amplify small differences in methyl-lysine recognition, simultaneously allowing for a dynamic chromatin architecture.
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Multivalent engagement of chromatin modifications by linked binding modules.

Alexander J. Ruthenburg, +3 more
- 01 Dec 2007 - 
TL;DR: It is proposed that multivalent interactions on a single histone tail and beyond may have a significant, if not dominant, role in chromatin transactions.
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Regulation of MLL1 H3K4 methyltransferase activity by its core components

Yali Dou, +8 more
- 30 Jul 2006 - 
TL;DR: This study reports the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex and demonstrates that WDR5 mediates interactions of the MLL1 catalytic unit both with the common structural platform and with the histone substrate.
Journal ArticleDOI

Recognition of a Mononucleosomal Histone Modification Pattern by BPTF via Multivalent Interactions

Alexander J. Ruthenburg, +10 more
- 27 May 2011 - 
TL;DR: This work examines how additional heterotypic modifications influence BPTF binding and calls attention to nucleosomal patterning of covalent marks in dictating critical chromatin associations.