T
Thomas A. Milne
Researcher at University of Oxford
Publications - 89
Citations - 11213
Thomas A. Milne is an academic researcher from University of Oxford. The author has contributed to research in topics: Gene & Regulation of gene expression. The author has an hindex of 37, co-authored 78 publications receiving 10049 citations. Previous affiliations of Thomas A. Milne include University of British Columbia & Rockefeller University.
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Journal ArticleDOI
A PHD finger of NURF couples histone H3 lysine 4 trimethylation with chromatin remodelling
Joanna Wysocka,Tomek Swigut,Hua Xiao,Thomas A. Milne,So Yeon Kwon,Joseph Landry,Monika Kauer,Alan J. Tackett,Brian T. Chait,Paul Badenhorst,Carl Wu,C. David Allis +11 more
TL;DR: This work shows that a plant homeodomain (PHD) finger of nucleosome remodelling factor (NURF), an ISWI-containing ATP-dependent chromatin-remodelling complex, mediates a direct preferential association with H3K4me3 tails, and identifies a previously unknown function for the PHD finger as a highly specialized methyl-lysine-binding domain.
Journal ArticleDOI
MLL targets SET domain methyltransferase activity to Hox gene promoters.
Thomas A. Milne,Scott D. Briggs,Hugh W. Brock,Mary Ellen Martin,Denise Gibbs,C. David Allis,Jay L. Hess +6 more
TL;DR: It is shown that MLL regulates target Hox gene expression through direct binding to promoter sequences and the MLL SET domain is a histone H3 lysine 4-specific methyltransferase whose activity is stimulated with acetylated H3 peptides.
Journal ArticleDOI
WDR5 Associates with Histone H3 Methylated at K4 and Is Essential for H3 K4 Methylation and Vertebrate Development
Joanna Wysocka,Tomek Swigut,Thomas A. Milne,Yali Dou,Xin Zhang,Alma L. Burlingame,Robert G. Roeder,Ali H. Brivanlou,C. David Allis +8 more
TL;DR: The results are the first demonstration that a WD40-repeat protein acts as a module for recognition of a specific histone modification and suggest a mechanism for reading and writing an epigenetic mark for gene activation.
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Regulation of MLL1 H3K4 methyltransferase activity by its core components
Yali Dou,Thomas A. Milne,Alexander J. Ruthenburg,Alexander J. Ruthenburg,Seunghee Lee,Jae Woon Lee,Gregory L. Verdine,C. David Allis,Robert G. Roeder +8 more
TL;DR: This study reports the first biochemical reconstitution of a functional four-component mixed-lineage leukemia protein-1 (MLL1) core complex and demonstrates that WDR5 mediates interactions of the MLL1 catalytic unit both with the common structural platform and with the histone substrate.
Journal ArticleDOI
Physical Association and Coordinate Function of the H3 K4 Methyltransferase MLL1 and the H4 K16 Acetyltransferase MOF
Yali Dou,Thomas A. Milne,Thomas A. Milne,Alan J. Tackett,Edwin R. Smith,Aya Fukuda,Joanna Wysocka,C. David Allis,Brian T. Chait,Jay L. Hess,Robert G. Roeder +10 more
TL;DR: An activator-based mechanism for joint MLL1 and MOF recruitment and targetedmethylation and acetylation is indicated and a molecular explanation for the closely correlated distribution of H3 K4 methylation and H4 K16 acetylations on active genes is provided.