S
Seungsoo Kim
Researcher at University of Washington
Publications - 16
Citations - 1086
Seungsoo Kim is an academic researcher from University of Washington. The author has contributed to research in topics: Transcription factor & Gene. The author has an hindex of 7, co-authored 12 publications receiving 736 citations. Previous affiliations of Seungsoo Kim include Harvard University.
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Journal ArticleDOI
A Genome-wide Framework for Mapping Gene Regulation via Cellular Genetic Screens.
Molly Gasperini,Andrew J. Hill,José L. McFaline-Figueroa,Beth Martin,Seungsoo Kim,Melissa D. Zhang,Dana Jackson,Anh Leith,Jacob Schreiber,William Stafford Noble,Cole Trapnell,Nadav Ahituv,Jay Shendure,Jay Shendure +13 more
TL;DR: A multiplex, expression quantitative trait locus (eQTL)-inspired framework for mapping enhancer-gene pairs by introducing random combinations of CRISPR/Cas9-mediated perturbations to each of many cells, followed by single-cell RNA sequencing (RNA-seq).
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Alternating antibiotic treatments constrain evolutionary paths to multidrug resistance
TL;DR: Using experimental evolution and whole-genome sequencing, it is found that alternating drugs slows the rate of increase in resistance compared with single-drug treatments, by constraining resistance mutations with trade-offs in resistance to a second drug.
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Delayed commitment to evolutionary fate in antibiotic resistance fitness landscapes.
Adam C. Palmer,Erdal Toprak,Erdal Toprak,Michael H. Baym,Seungsoo Kim,Adrian Veres,Shimon Bershtein,Roy Kishony,Roy Kishony +8 more
TL;DR: A multi-peaked adaptive landscape for trimethoprim resistance is characterized by constructing all combinatorial alleles of seven resistance-conferring mutations in dihydrofolate reductase, observing that epistatic interactions increase rather than decrease the accessibility of each peak.
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Mechanisms of Interplay between Transcription Factors and the 3D Genome
TL;DR: This review summarizes the evidence for the diverse mechanisms by which TFs and their activity shape the 3D genome and vice versa and highlights outstanding questions and potential approaches for untangling the complex relation between TF activity and the3D genome.
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Condensin-Dependent Chromatin Compaction Represses Transcription Globally during Quiescence.
Sarah G. Swygert,Seungsoo Kim,Xiaoying Wu,Tianhong Fu,Tsung-Han S. Hsieh,Oliver J. Rando,Robert N. Eisenman,Jay Shendure,Jay Shendure,Jeffrey N. McKnight,Toshio Tsukiyama +10 more
TL;DR: This work uses Micro-C XL to map chromatin contacts at single-nucleosome resolution genome-wide in quiescent Saccharomyces cerevisiae cells and demonstrates that condensin-dependent chromatin compaction is conserved in quyingcent human fibroblasts.