S
Sha Mi
Researcher at Biogen Idec
Publications - 82
Citations - 6333
Sha Mi is an academic researcher from Biogen Idec. The author has contributed to research in topics: Oligodendrocyte & Oligodendrocyte differentiation. The author has an hindex of 27, co-authored 80 publications receiving 5890 citations. Previous affiliations of Sha Mi include Genetics Institute, Inc..
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Journal ArticleDOI
Syncytin is a captive retroviral envelope protein involved in human placental morphogenesis.
Sha Mi,Xinhua Lee,Xiangping Li,Geertruida M. Veldman,Heather Finnerty,Lisa A. Racie,Edward R. Lavallie,Xiang-Yang Tang,Philippe Edouard,Steve Howes,James C. Keith,John M. Mccoy,John M. Mccoy +12 more
TL;DR: It is shown that expression of recombinant syncytin in a wide variety of cell types induces the formation of giant syncytia, and that fusion of a human trophoblastic cell line expressing endogenousSyncytin can be inhibited by an anti-syncytin antiserum, and thus may be important in human placental morphogenesis.
Journal ArticleDOI
LINGO-1 is a component of the Nogo-66 receptor/p75 signaling complex.
Sha Mi,Xinhua Lee,Zhaohui Shao,Greg Thill,Benxiu Ji,Jane K. Relton,Melissa Levesque,Norm Allaire,Steve Perrin,Bryan Sands,Thomas Crowell,Richard L. Cate,John M. Mccoy,R. Blake Pepinsky +13 more
TL;DR: In non-neuronal cells, coexpression of human NgR1, p75 and LINGO-1 conferred responsiveness to oligodendrocyte myelin glycoprotein, as measured by RhoA activation, which suggests that Lingo-1 has an important role in CNS biology.
Journal ArticleDOI
LINGO-1 negatively regulates myelination by oligodendrocytes.
Sha Mi,Robert H. Miller,Xinhua Lee,Martin L. Scott,Svetlane Shulag-Morskaya,Zhaohui Shao,Jufang Chang,Greg Thill,Melissa Levesque,Mingdi Zhang,C Hession,Dinah W. Y. Sah,Bruce D. Trapp,Zhigang He,Vincent Jung,John M. Mccoy,R. Blake Pepinsky +16 more
TL;DR: The ability to recapitulate CNS myelination in vitro using LINGO-1 antagonists and the in vivo effects seen in the LINGo-1 knockout indicate that Lingo-1 signaling may be critical for CNSMyelination.
Journal ArticleDOI
LINGO-1 antagonist promotes spinal cord remyelination and axonal integrity in MOG-induced experimental autoimmune encephalomyelitis
Sha Mi,Bing Hu,Bing Hu,Kyungmin Hahm,Yi Luo,Edward S. Hui,Qiuju Yuan,Wai-Man Wong,Li Wang,Huanxing Su,Tak-Ho Chu,Jiasong Guo,Wenming Zhang,Kwok-Fai So,Pepinsky R Blake,Zhaohui Shao,Christilyn Graff,Ellen Garber,Vincent Jung,Ed X. Wu,Wutian Wu,Wutian Wu +21 more
TL;DR: Antagonism of LINGO-1 or its pathway is a promising approach for the treatment of demyelinating diseases of the CNS by reflected biologically by improved axonal integrity, as confirmed by magnetic resonance diffusion tensor imaging, and by newly formed myelin sheaths, as determined by electron microscopy.
Journal ArticleDOI
TAJ/TROY, an Orphan TNF Receptor Family Member, Binds Nogo-66 Receptor 1 and Regulates Axonal Regeneration
Zhaohui Shao,Jeffrey L. Browning,Xinhua Lee,Martin L. Scott,Sveltlana Shulga-Morskaya,Norm Allaire,Greg Thill,Melissa Levesque,Dinah W. Y. Sah,John M. Mccoy,Beth L. Murray,Vincent Jung,R. Blake Pepinsky,Sha Mi +13 more
TL;DR: It is shown that an orphan receptor in the TNF family called TAJ, broadly expressed in postnatal and adult neurons, binds to NgR1 and can replace p75 in the p75/NgR1/LINGO-1 complex to activate RhoA in the presence of myelin inhibitors.