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Yuyu Niu
Researcher at Kunming University of Science and Technology
Publications - 90
Citations - 3727
Yuyu Niu is an academic researcher from Kunming University of Science and Technology. The author has contributed to research in topics: Biology & Embryonic stem cell. The author has an hindex of 22, co-authored 75 publications receiving 2887 citations. Previous affiliations of Yuyu Niu include Kunming Institute of Zoology & Leibniz Association.
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Journal ArticleDOI
Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
Yuyu Niu,Bin Shen,Yiqiang Cui,Yongchang Chen,Jianying Wang,Lei Wang,Yu Kang,Xiaoyang Zhao,Wei Si,Wei Li,Andy Peng Xiang,Jiankui Zhou,Xuejiang Guo,Ye Bi,Chenyang Si,Bian Hu,Guoying Dong,Hong Wang,Zuomin Zhou,Tianqing Li,Tao Tan,Xiuqiong Pu,Fang Wang,Shaohui Ji,Qi Zhou,Xingxu Huang,Weizhi Ji,Jiahao Sha +27 more
TL;DR: By coinjection of Cas9 mRNA and sgRNAs into one-cell-stage embryos, this system successfully achieves precise gene targeting in cynomolgus monkeys and enables simultaneous disruption of two target genes in one step, and no off-target mutagenesis was detected by comprehensive analysis.
Journal ArticleDOI
Genome of the Chinese tree shrew
Yu Fan,Zhiyong Huang,Chang-Chang Cao,Ceshi Chen,Yuanxin Chen,Dingding Fan,Jing He,Haolong Hou,Li Hu,Xintian Hu,Xuanting Jiang,Ren Lai,Yongshan Lang,Bin Liang,Shengguang Liao,Dan Mu,Dan Mu,Yuanye Ma,Yuyu Niu,Xiaoqing Sun,Jinquan Xia,Jin Xiao,Zhiqiang Xiong,Lin Xu,Lan Yang,Yun Zhang,Wei Zhao,Xudong Zhao,Yong-Tang Zheng,Ju-Min Zhou,Yabing Zhu,Guojie Zhang,Guojie Zhang,Jun Wang,Yong-Gang Yao +34 more
TL;DR: It is demonstrated that tree shrews possess both shared common and unique features, and the genetic basis for the use of this animal as a potential model for biomedical research is provided.
Journal ArticleDOI
A developmental landscape of 3D-cultured human pre-gastrulation embryos.
Lifeng Xiang,Yu Yin,Yu Yin,Yun Zheng,Yun Zheng,Yanping Ma,Yonggang Li,Zhigang Zhao,Junqiang Guo,Zongyong Ai,Zongyong Ai,Yuyu Niu,Yuyu Niu,Kui Duan,Kui Duan,Jingjing He,Jingjing He,Shuchao Ren,Dan Wu,Yun Bai,Zhouchun Shang,Xi Dai,Weizhi Ji,Weizhi Ji,Tianqing Li,Tianqing Li +25 more
TL;DR: A 3D culture system to model human embryonic development, together with single-cell transcriptome profiling, provides insights into the molecular developmental landscape during human post-implantation embryogenesis.
Journal ArticleDOI
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
Yongchang Chen,Yinghui Zheng,Yu Kang,Weili Yang,Yuyu Niu,Xiangyu Guo,Zhuchi Tu,Chenyang Si,Hong Wang,Ruxiao Xing,Xiuqiong Pu,Shang Hsun Yang,Shihua Li,Weizhi Ji,Xiao-Jiang Li +14 more
TL;DR: The findings indicate that CRISPR/Cas9 can efficiently generate monkey models of human diseases, regardless of inheritance patterns, and the presence of degenerated muscle cells in newborn Cas9-targeted monkeys suggests that therapeutic interventions at the early disease stage may be effective at alleviating the myopathy.
Journal ArticleDOI
TALEN-Mediated Gene Mutagenesis in Rhesus and Cynomolgus Monkeys
Hailiang Liu,Yongchang Chen,Yuyu Niu,Kunshan Zhang,Yu Kang,Weihong Ge,Xiaojing Liu,Enfeng Zhao,Chencheng Wang,Shaoyun Lin,Bo Jing,Chenyang Si,Quan Lin,Quan Lin,Xiaoying Chen,Xiaoying Chen,Haijun Lin,Xiuqiong Pu,Yingying Wang,Binlian Qin,Fang Wang,Hong Wang,Wei Si,Jing Zhou,Tao Tan,Tianqing Li,Shaohui Ji,Zhigang Xue,Yuping Luo,Liming Cheng,Qi Zhou,Siguang Li,Yi E. Sun,Yi E. Sun,Weizhi Ji +34 more
TL;DR: It is concluded that TALEN-mediated mutagenesis can be an effective tool for genetic modeling of human disease in nonhuman primates.