W
Weizhi Ji
Researcher at Kunming University of Science and Technology
Publications - 161
Citations - 5790
Weizhi Ji is an academic researcher from Kunming University of Science and Technology. The author has contributed to research in topics: Embryonic stem cell & Cellular differentiation. The author has an hindex of 30, co-authored 141 publications receiving 4766 citations. Previous affiliations of Weizhi Ji include Chinese Academy of Sciences & World Economic Forum.
Papers
More filters
Journal ArticleDOI
Generation of Gene-Modified Cynomolgus Monkey via Cas9/RNA-Mediated Gene Targeting in One-Cell Embryos
Yuyu Niu,Bin Shen,Yiqiang Cui,Yongchang Chen,Jianying Wang,Lei Wang,Yu Kang,Xiaoyang Zhao,Wei Si,Wei Li,Andy Peng Xiang,Jiankui Zhou,Xuejiang Guo,Ye Bi,Chenyang Si,Bian Hu,Guoying Dong,Hong Wang,Zuomin Zhou,Tianqing Li,Tao Tan,Xiuqiong Pu,Fang Wang,Shaohui Ji,Qi Zhou,Xingxu Huang,Weizhi Ji,Jiahao Sha +27 more
TL;DR: By coinjection of Cas9 mRNA and sgRNAs into one-cell-stage embryos, this system successfully achieves precise gene targeting in cynomolgus monkeys and enables simultaneous disruption of two target genes in one step, and no off-target mutagenesis was detected by comprehensive analysis.
Journal ArticleDOI
Species Variation in the Mechanisms of Mesenchymal Stem Cell‐Mediated Immunosuppression
Guangwen Ren,Juanjuan Su,Juanjuan Su,Liying Zhang,Xin Zhao,Weifang Ling,Andrew L'huillie,Jimin Zhang,Yongqing Lu,Yongqing Lu,Arthur I. Roberts,Weizhi Ji,Huatang Zhang,Arnold B. Rabson,Yufang Shi,Yufang Shi,Yufang Shi +16 more
TL;DR: Bone marrow‐derived mesenchymal stem cells (MSCs) hold great promise for treating immune disorders because of their immunoregulatory capacity, but the mechanism remains controversial, as it is shown here, the mechanism of MSC‐mediated immunosuppression varies among different species.
Journal ArticleDOI
Generation of Induced Pluripotent Stem Cells from Adult Rhesus Monkey Fibroblasts
Haisong Liu,Fangfang Zhu,Jun Yong,Pengbo Zhang,Pingping Hou,Honggang Li,Wei Jiang,Jun Cai,Meng Liu,Kai Cui,Xiuxia Qu,Tingting Xiang,Danyu Lu,Xiaochun Chi,Ge Gao,Weizhi Ji,Mingxiao Ding,Hongkui Deng +17 more
TL;DR: In this article, a retrovirus-mediated introduction of monkey transcription factors OCT4, SOX2, KLF4, and c-MYC was used to generate monkey induced pluripotent stem cells.
Journal ArticleDOI
A developmental landscape of 3D-cultured human pre-gastrulation embryos.
Lifeng Xiang,Yu Yin,Yu Yin,Yun Zheng,Yun Zheng,Yanping Ma,Yonggang Li,Zhigang Zhao,Junqiang Guo,Zongyong Ai,Zongyong Ai,Yuyu Niu,Yuyu Niu,Kui Duan,Kui Duan,Jingjing He,Jingjing He,Shuchao Ren,Dan Wu,Yun Bai,Zhouchun Shang,Xi Dai,Weizhi Ji,Weizhi Ji,Tianqing Li,Tianqing Li +25 more
TL;DR: A 3D culture system to model human embryonic development, together with single-cell transcriptome profiling, provides insights into the molecular developmental landscape during human post-implantation embryogenesis.
Journal ArticleDOI
Functional disruption of the dystrophin gene in rhesus monkey using CRISPR/Cas9
Yongchang Chen,Yinghui Zheng,Yu Kang,Weili Yang,Yuyu Niu,Xiangyu Guo,Zhuchi Tu,Chenyang Si,Hong Wang,Ruxiao Xing,Xiuqiong Pu,Shang Hsun Yang,Shihua Li,Weizhi Ji,Xiao-Jiang Li +14 more
TL;DR: The findings indicate that CRISPR/Cas9 can efficiently generate monkey models of human diseases, regardless of inheritance patterns, and the presence of degenerated muscle cells in newborn Cas9-targeted monkeys suggests that therapeutic interventions at the early disease stage may be effective at alleviating the myopathy.