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Shaodong Zhang
Researcher at Shanghai Jiao Tong University
Publications - 47
Citations - 1629
Shaodong Zhang is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Medicine & Homochirality. The author has an hindex of 16, co-authored 35 publications receiving 1226 citations. Previous affiliations of Shaodong Zhang include University of Paris & University of Pennsylvania.
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From structure to function via complex supramolecular dendrimer systems.
TL;DR: This tutorial review summarizes strategies elaborated for the discovery and prediction of programmed primary structures derived from quasi-equivalent constitutional isomeric libraries of self-assembling dendrons, dendrimers and dendronized polymers that demonstrate an 82% predictability.
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Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins
Virgil Percec,Pawaret Leowanawat,Hao-Jan Sun,Oleg V. Kulikov,Christopher D. Nusbaum,Tam Tran,Annabelle Bertin,Daniela A. Wilson,Mihai Peterca,Shaodong Zhang,Neha P. Kamat,Kevin B. Vargo,Diana Moock,Eric D. Johnston,Daniel A. Hammer,Darrin J. Pochan,Yingchao Chen,Yoann M. Chabre,Tze Chieh Shiao,Milan Bergeron-Brlek,Sabine André,René Roy,Hans J. Gabius,Paul A. Heiney +23 more
TL;DR: The results demonstrated the candidacy of glycodendrimersomes as new mimics of biological membranes with programmable glycan ligand presentations, as supramolecular lectin blockers, vaccines, and targeted delivery devices.
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Self-assembly of amphiphilic Janus dendrimers into uniform onion-like dendrimersomes with predictable size and number of bilayers.
Shaodong Zhang,Hao-Jan Sun,Andrew D. Hughes,Ralph-Olivier Moussodia,Annabelle Bertin,Yingchao Chen,Darrin J. Pochan,Paul A. Heiney,Michael L. Klein,Virgil Percec +9 more
TL;DR: Six amphiphilic Janus dendrimer primary structures self-assemble into uniform onion-like vesicles, which provide mimics of double-bilayer and multibilayer biological membranes with dimensions and number of bilayers predicted by the Janus compound concentration in water.
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Mimicking biological membranes with programmable glycan ligands self-assembled from amphiphilic Janus glycodendrimers.
Shaodong Zhang,Ralph-Olivier Moussodia,Hao-Jan Sun,Pawaret Leowanawat,Adam Muncan,Christopher D. Nusbaum,Kathleen M. Chelling,Paul A. Heiney,Michael L. Klein,Sabine André,René Roy,Hans-J. Gabius,Virgil Percec +12 more
TL;DR: An accelerated modular synthesis produced 18 amphiphilic Janus glycodendrimers with three different topologies formed from either two or one carbohydrate head groups or a mixed constellation with a noncarbohydrate hydrophilic arm that were demonstrated to be most efficient in binding plant, bacterial, and human lectins.
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Dissecting Molecular Aspects of Cell Interactions Using Glycodendrimersomes with Programmable Glycan Presentation and Engineered Human Lectins
Shaodong Zhang,Ralph-Olivier Moussodia,Claire M. Murzeau,Hao-Jan Sun,Michael L. Klein,Sabine Vértesy,Sabine André,René Roy,Hans-Joachim Gabius,Virgil Percec +9 more
TL;DR: These findings highlight the value of glycodendrimersomes as versatile cell membrane mimetics, and assays provide diagnostic tools for protein functionality, and provide guidelines for the design of cell separators, bioactive matrices, bioeffectors, and other biomedical applications.