M
Milan Bergeron-Brlek
Researcher at Simon Fraser University
Publications - 11
Citations - 447
Milan Bergeron-Brlek is an academic researcher from Simon Fraser University. The author has contributed to research in topics: Catalysis & Iminosugar. The author has an hindex of 7, co-authored 11 publications receiving 381 citations. Previous affiliations of Milan Bergeron-Brlek include Université du Québec à Montréal.
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Journal ArticleDOI
Modular Synthesis of Amphiphilic Janus Glycodendrimers and Their Self-Assembly into Glycodendrimersomes and Other Complex Architectures with Bioactivity to Biomedically Relevant Lectins
Virgil Percec,Pawaret Leowanawat,Hao-Jan Sun,Oleg V. Kulikov,Christopher D. Nusbaum,Tam Tran,Annabelle Bertin,Daniela A. Wilson,Mihai Peterca,Shaodong Zhang,Neha P. Kamat,Kevin B. Vargo,Diana Moock,Eric D. Johnston,Daniel A. Hammer,Darrin J. Pochan,Yingchao Chen,Yoann M. Chabre,Tze Chieh Shiao,Milan Bergeron-Brlek,Sabine André,René Roy,Hans J. Gabius,Paul A. Heiney +23 more
TL;DR: The results demonstrated the candidacy of glycodendrimersomes as new mimics of biological membranes with programmable glycan ligand presentations, as supramolecular lectin blockers, vaccines, and targeted delivery devices.
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A tandem organocatalytic α-chlorination–aldol reaction that proceeds with dynamic kinetic resolution: a powerful tool for carbohydrate synthesis
TL;DR: In this article, a tandem, proline-catalyzed α-chlorination/aldol reaction is described, which involves a dynamic kinetic resolution of α -chloroaldehyde intermediates, and the resulting syn-chlorohydrins are produced with good to excellent diastereoselectivity in high enantiopurity.
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Direct synthesis of imino- C -nucleoside analogues and other biologically active iminosugars
TL;DR: A unique synthetic strategy that converts a wide range of acetaldehyde derivatives into iminosugars and imino-C-nucleoside analogues in two or three straightforward transformations is described, and can be readily applied to the rapid production of indolizidine and pyrrolizidine iminosUGars.
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A Convenient Approach to Stereoisomeric Iminocyclitols: Generation of Potent Brain‐Permeable OGA Inhibitors
Milan Bergeron-Brlek,Jake Goodwin‐Tindall,Nevena Cekic,Christian Roth,Wesley F. Zandberg,Xiaoyang Shan,Vimal Varghese,Sherry Chan,Gideon J. Davies,David J. Vocadlo,Robert Britton +10 more
TL;DR: Pyrrolidine-based iminocyclitols are a promising class of glycosidase inhibitors that permeate into rodent brain to increase O-GlcNAc, and should prove useful tools for studying the role of OGA in health and disease.
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Synthesis of a small library of bivalent α-D-mannopyranosides for lectin cross-linking.
TL;DR: A small library of bivalent α-D-mannopyranosides having rigid linkers was constructed in order to evaluate the effects of inter-saccharide distances upon multivalent binding interactions with plant and bacterial lectins.