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Shashi Bhushan
Researcher at LSU Health Sciences Center New Orleans
Publications - 37
Citations - 1690
Shashi Bhushan is an academic researcher from LSU Health Sciences Center New Orleans. The author has contributed to research in topics: Computer science & Heart failure. The author has an hindex of 16, co-authored 30 publications receiving 1466 citations. Previous affiliations of Shashi Bhushan include Emory University.
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Journal ArticleDOI
H2S Protects Against Pressure Overload Induced Heart Failure via Upregulation of Endothelial Nitric Oxide Synthase (eNOS)
Kazuhisa Kondo,Shashi Bhushan,Adrienne L. King,Sumanth D. Prabhu,Tariq Hamid,Steven C. Koenig,Toyoaki Murohara,Benjamin L. Predmore,Gabriel Gojon,Rui Wang,Naveena Karusula,Chad K. Nicholson,John W. Calvert,David J. Lefer +13 more
TL;DR: H2S levels are decreased in mice in the setting of heart failure, and oral H2S therapy prevents the transition from compensated to decompensated heart failure in part via upregulation of endothelial nitric oxide synthase and increased Nitric oxide bioavailability.
Journal ArticleDOI
Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent
Adrienne L. King,David J. Polhemus,Shashi Bhushan,Hiroyuki Otsuka,Kazuhisa Kondo,Chad K. Nicholson,Jessica M. Bradley,Kazi N. Islam,John W. Calvert,Ya-Xiong Tao,Tammy R. Dugas,Eric E. Kelley,John W. Elrod,Paul L. Huang,Rui Wang,David J. Lefer +15 more
TL;DR: The results suggest that H2S-mediated cytoprotective signaling in the setting of I/R injury is dependent in large part on eNOS activation and NO generation, and indicates that hydrogen sulfide protects against multiple cardiovascular disease states in a similar manner as nitric oxide.
Journal ArticleDOI
The polysulfide diallyl trisulfide protects the ischemic myocardium by preservation of endogenous hydrogen sulfide and increasing nitric oxide bioavailability
Benjamin L. Predmore,Kazuhisa Kondo,Shashi Bhushan,Maxim A. Zlatopolsky,Adrienne L. King,Juan Pablo Aragon,D. Bennett Grinsfelder,Marah E. Condit,David J. Lefer +8 more
TL;DR: DATS is a donor of H(2)S that can be used as a cardioprotective agent to treat MI/R injury in vivo and is suggested to significantly induce the Nrf2 pathway.
Journal ArticleDOI
Controllable hydrogen sulfide donors and their activity against myocardial ischemia-reperfusion injury.
Yu Zhao,Shashi Bhushan,Chun-Tao Yang,Hiroyuki Otsuka,Jason D. Stein,Armando Pacheco,Bo Peng,Nelmi O. Devarie-Baez,Hector C. Aguilar,David J. Lefer,Ming Xian +10 more
TL;DR: The design, synthesis, and biological evaluation of a new class of controllable H2S donors based on a perthiol template, which showed potent protective effects in an in vivo murine model of myocardial ischemia-reperfusion injury, through a H 2S-related mechanism are reported.
Journal ArticleDOI
Hydrogen Sulfide Attenuates Cardiac Dysfunction After Heart Failure Via Induction of Angiogenesis
David J. Polhemus,Kazuhisa Kondo,Shashi Bhushan,Shyamal C. Bir,Christopher G. Kevil,Toyoaki Murohara,David J. Lefer,John W. Calvert +7 more
TL;DR: These results suggest that H2S therapy attenuates left ventricular remodeling and dysfunction in the setting of heart failure by creating a proangiogenic environment for the growth of new vessels.