E
Eric E. Kelley
Researcher at West Virginia University
Publications - 108
Citations - 5200
Eric E. Kelley is an academic researcher from West Virginia University. The author has contributed to research in topics: Nitric oxide & Xanthine oxidase. The author has an hindex of 35, co-authored 89 publications receiving 4255 citations. Previous affiliations of Eric E. Kelley include University of Alabama at Birmingham & University of Pittsburgh.
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Journal ArticleDOI
Nitric oxide scavenging by red blood cell microparticles and cell-free hemoglobin as a mechanism for the red cell storage lesion.
Chenell Donadee,Nicolaas J.H. Raat,Tamir Kanias,Jesús Tejero,Janet S. Lee,Eric E. Kelley,Xuejun Zhao,Chen Liu,Hannah Reynolds,Ivan Azarov,Sheila Frizzell,E. Michael Meyer,Albert D. Donnenberg,Lirong Qu,Darrel Triulzi,Daniel B. Kim-Shapiro,Mark T. Gladwin +16 more
TL;DR: Two complementary in vivo studies suggest new mechanisms for endothelial injury and impaired vascular function associated with the most fundamental of storage lesions, hemolysis.
Journal ArticleDOI
Hydrogen peroxide is the major oxidant product of xanthine oxidase
Eric E. Kelley,Nicholas K.H. Khoo,Nicholas J. Hundley,Umair Z. Malik,Bruce A. Freeman,Margaret M. Tarpey,Margaret M. Tarpey +6 more
TL;DR: H(2)O(2), by binding to heparin-Sepharose, is established as the dominant reactive product produced by XO under clinically relevant conditions and is emphasized as a critical factor when examining the contributory roles of XO-catalyzed ROS in inflammatory processes as well as cellular signaling.
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Hydrogen sulfide cytoprotective signaling is endothelial nitric oxide synthase-nitric oxide dependent
Adrienne L. King,David J. Polhemus,Shashi Bhushan,Hiroyuki Otsuka,Kazuhisa Kondo,Chad K. Nicholson,Jessica M. Bradley,Kazi N. Islam,John W. Calvert,Ya-Xiong Tao,Tammy R. Dugas,Eric E. Kelley,John W. Elrod,Paul L. Huang,Rui Wang,David J. Lefer +15 more
TL;DR: The results suggest that H2S-mediated cytoprotective signaling in the setting of I/R injury is dependent in large part on eNOS activation and NO generation, and indicates that hydrogen sulfide protects against multiple cardiovascular disease states in a similar manner as nitric oxide.
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An aged immune system drives senescence and ageing of solid organs.
Matthew J. Yousefzadeh,Rafael R. Flores,Yi Zhu,Zoe C. Schmiechen,Robert W. Brooks,Christy E. Trussoni,Yuxiang Cui,Luise A. Angelini,Kyoo a. Lee,Sara J. McGowan,Adam L. Burrack,Dong Wang,Qing Dong,Aiping Lu,Tokio Sano,Ryan D. O’Kelly,Collin A. McGuckian,Jonathan I. Kato,Michael P. Bank,Erin A. Wade,Smitha P. S. Pillai,Jenna Klug,Warren C. Ladiges,Christin E. Burd,Sara E. Lewis,Nicholas F. LaRusso,Nam Vo,Yinsheng Wang,Eric E. Kelley,Johnny Huard,Ingunn M. Stromnes,Paul D. Robbins,Laura J. Niedernhofer +32 more
TL;DR: In this paper, the contribution of immune system ageing to organism ageing was defined by selectively deleting Ercc1, which encodes a crucial DNA repair protein, in mouse haematopoietic cells to increase the burden of endogenous DNA damage and thereby senescence.
Journal ArticleDOI
Oxidases and peroxidases in cardiovascular and lung disease: New concepts in reactive oxygen species signaling
Imad Al Ghouleh,Nicholas K.H. Khoo,Ulla G. Knaus,Kathy K. Griendling,Rhian M. Touyz,Victor J. Thannickal,Aaron Barchowsky,William M. Nauseef,William M. Nauseef,Eric E. Kelley,Phillip M. Bauer,Victor M. Darley-Usmar,Sruti Shiva,Eugenia Cifuentes-Pagano,Bruce A. Freeman,Mark T. Gladwin,Patrick J. Pagano +16 more
TL;DR: This review is based on the proceedings of a recent international Oxidase Signaling Symposium at the University of Pittsburgh's Vascular Medicine Institute and Department of Pharmacology and Chemical Biology and encompasses further interaction and discussion among the presenters.