S
Shawn R. Gilbert
Researcher at University of Alabama at Birmingham
Publications - 77
Citations - 2637
Shawn R. Gilbert is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Medicine & Angiogenesis. The author has an hindex of 18, co-authored 66 publications receiving 2221 citations. Previous affiliations of Shawn R. Gilbert include University of North Carolina at Chapel Hill & University of Alabama.
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Journal ArticleDOI
The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
Ying Wang,Chao Wan,Lianfu Deng,Ximeng Liu,Xuemei Cao,Shawn R. Gilbert,Mary L. Bouxsein,Marie Claude Faugere,Robert E. Guldberg,Louis C. Gerstenfeld,Volker H. Haase,Randall S. Johnson,Ernestina Schipani,Thomas L. Clemens,Thomas L. Clemens +14 more
TL;DR: It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone.
Journal ArticleDOI
Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration
Chao Wan,Shawn R. Gilbert,Ying Wang,Xuemei Cao,Xing Shen,Girish Ramaswamy,Kimberly A. Jacobsen,Zainab S Al-Aql,Alan W. Eberhardt,Louis C. Gerstenfeld,Thomas A. Einhorn,Lianfu Deng,Thomas L. Clemens,Thomas L. Clemens +13 more
TL;DR: The HIF-1α pathway is identified as a critical mediator of neoangiogenesis required for skeletal regeneration and the application of HIF activators as therapies to improve bone healing is suggested.
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Prolyl hydroxylase inhibitors increase neoangiogenesis and callus formation following femur fracture in mice
Xing Shen,Chao Wan,Girish Ramaswamy,Mahendra Mavalli,Ying Wang,Craig L. Duvall,Lian Fu Deng,Robert E. Guldberg,Alan Eberhart,Thomas L. Clemens,Shawn R. Gilbert +10 more
TL;DR: It is suggested that HIF activation is a viable approach to increase vascularity and bone formation following skeletal trauma and in a stabilized fracture model in vivo.
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Bone Formation During Distraction Osteogenesis Is Dependent on Both VEGFR1 and VEGFR2 Signaling
Kimberly A. Jacobsen,Zainab S Al-Aql,Chao Wan,Jennifer L Fitch,Stephanie Stapleton,Zachary D. Mason,Robert M Cole,Shawn R. Gilbert,Thomas L. Clemens,Elise F. Morgan,Thomas A. Einhorn,Louis C. Gerstenfeld +11 more
TL;DR: This work has shown that the preoperatively induced induction of highly vascularized new bone formation through an intramembranous process largely devoid of the formation of cartilage in mice is a viable process.
Journal ArticleDOI
Role of HIF-1α in skeletal development
Chao Wan,Jin Shao,Shawn R. Gilbert,Ryan C. Riddle,Fanxin Long,Randall S. Johnson,Ernestina Schipani,Thomas L. Clemens +7 more
TL;DR: It is demonstrated that overexpression of HIF‐1 in mature osteoblasts through disruption of the von Hippel‐Lindau protein profoundly increases angiogenesis and osteogenesis; these processes appear to be coupled by cell nonautonomous mechanisms involving the action of vascular endothelial growth factor (VEGF) on the endothelial cells.