C
Chao Wan
Researcher at The Chinese University of Hong Kong
Publications - 53
Citations - 6076
Chao Wan is an academic researcher from The Chinese University of Hong Kong. The author has contributed to research in topics: Mesenchymal stem cell & Angiogenesis. The author has an hindex of 29, co-authored 47 publications receiving 5404 citations. Previous affiliations of Chao Wan include Johns Hopkins University School of Medicine & Queen's University Belfast.
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Journal ArticleDOI
TGF-Β1-induced migration of bone mesenchymal stem cells couples bone resorption with formation
Yi Tang,Xiangwei Wu,Xiangwei Wu,Xiangwei Wu,Weiqi Lei,Lijuan Pang,Lijuan Pang,Chao Wan,Zhenqi Shi,Ling Zhao,Tim R. Nagy,Xinyu Peng,Junbo Hu,Xu Feng,Wim Van Hul,Mei Wan,Xu Cao +16 more
TL;DR: It is shown using in vitro and in vivo models that active TGF-β1 released during bone resorption coordinates bone formation by inducing migration of bone marrow stromal cells, also known as bone mesenchymal stem cells, to theBone resorptive sites and that this process is mediated through a SMAD signaling pathway.
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Insulin Receptor Signaling in Osteoblasts Regulates Postnatal Bone Acquisition and Body Composition
Keertik Fulzele,Ryan C. Riddle,Douglas J. DiGirolamo,Xuemei Cao,Chao Wan,Dongquan Chen,Marie Claude Faugere,Susan Aja,Mehboob A. Hussain,Jens C. Brüning,Jens C. Brüning,Thomas L. Clemens,Thomas L. Clemens +12 more
TL;DR: The results indicate the existence of a bone-pancreas endocrine loop through which insulin signaling in the osteoblasts ensures osteoblast differentiation and stimulates osteocalcin production, which in turn regulates insulin sensitivity and pancreatic insulin secretion.
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The hypoxia-inducible factor α pathway couples angiogenesis to osteogenesis during skeletal development
Ying Wang,Chao Wan,Lianfu Deng,Ximeng Liu,Xuemei Cao,Shawn R. Gilbert,Mary L. Bouxsein,Marie Claude Faugere,Robert E. Guldberg,Louis C. Gerstenfeld,Volker H. Haase,Randall S. Johnson,Ernestina Schipani,Thomas L. Clemens,Thomas L. Clemens +14 more
TL;DR: It is suggested that activation of the HIF alpha pathway in developing bone increases bone modeling events through cell-nonautonomous mechanisms to coordinate the timing, direction, and degree of new blood vessel formation in bone.
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Activation of the hypoxia-inducible factor-1α pathway accelerates bone regeneration
Chao Wan,Shawn R. Gilbert,Ying Wang,Xuemei Cao,Xing Shen,Girish Ramaswamy,Kimberly A. Jacobsen,Zainab S Al-Aql,Alan W. Eberhardt,Louis C. Gerstenfeld,Thomas A. Einhorn,Lianfu Deng,Thomas L. Clemens,Thomas L. Clemens +13 more
TL;DR: The HIF-1α pathway is identified as a critical mediator of neoangiogenesis required for skeletal regeneration and the application of HIF activators as therapies to improve bone healing is suggested.
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Concise Review: Multipotent Mesenchymal Stromal Cells in Blood
Qiling He,Chao Wan,Gang Li +2 more
TL;DR: In this review, current studies/knowledge about peripheral blood‐derived multipotent mesenchymal stromal cells is summarized, and the above‐mentioned topics are discussed.