Sherrie Secunda

TL;DR: The skin of poison frogs contains a wide variety of alkaloids that presumably serve a defensive role, and an alkaloid uptake system provides a means of maintaining skin alkaloidal levels and suggests that some if not all such 'dendrobatid alkal steroids' may have a dietary origin.

TL;DR: The present study assessed the effect of N6 and N-9 substituents on the binding of adenines to the A1 and A2 receptors of rat brain cortex and striatum and also on the antagonism of the A2 receptor mediated stimulation of the adenylate cyclase of PC12 cells by N-ethyladenosine-5'-uronamide.

TL;DR: The genetic, environmental and dietary determinants of alkaloid profiles in dendrobatid frogs remain obscure, in particular the underlying cause for total absence in terrarium-reared frogs.

TL;DR: Sulfur-containing analogues of 8-substituted xanthines were prepared in an effort to increase selectivity or potency as antagonists at adenosine receptors, and 2-Thio-8-aryl derivatives tended to be more potent at A2 receptors than the oxygen analogue.

TL;DR: It appears likely that some "inactive" congeners bind to the PTX-B binding site, but do not activate sodium channels, since pumiliotoxins, unlike local anesthetics, had little or no effect on binding of [3H]batrachotoxinin A benzoate to sodium channels.