S
Shin Ichi Nishikawa
Researcher at Kumamoto University
Publications - 10
Citations - 3726
Shin Ichi Nishikawa is an academic researcher from Kumamoto University. The author has contributed to research in topics: Stromal cell & B cell. The author has an hindex of 10, co-authored 10 publications receiving 3648 citations. Previous affiliations of Shin Ichi Nishikawa include Max Planck Society.
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Journal ArticleDOI
The murine mutation osteopetrosis is in the coding region of the macrophage colony stimulating factor gene
Hisahiro Yoshida,Shin-Ichi Hayashi,Takahiro Kunisada,Minetaro Ogawa,Satomi Nishikawa,Hitoshi Okamura,Tetsuo Sudo,Leonard D. Shultz,Shin Ichi Nishikawa +8 more
TL;DR: It is shown that op/op fibroblasts are defective in production of functional macrophage colony-stimulating factor (M-CSF), although its messenger RNA (Csfm mRNA) is present at normal levels, and it is concluded that the pathological changes in this mutant result from the absence of M- CSF.
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Expression and function of c-kit in hemopoietic progenitor cells
Minetaro Ogawa,Yumi Matsuzaki,Shin Ichi Nishikawa,S Hayashi,Takahiro Kunisada,Tetsuo Sudo,T. Kina,H Nakauchi +7 more
TL;DR: Results provide direct evidence that c-kit is an essential molecule for constitutive intramarrow hemopoiesis, especially for the self-renewal of hemopOietic progenitor cells at various stages of differentiation.
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In utero manipulation of coat color formation by a monoclonal anti-c-kit antibody: two distinct waves of c-kit-dependency during melanocyte development.
Shin Ichi Nishikawa,M. Kusakabe,K. Yoshinaga,Minetaro Ogawa,S Hayashi,Takahiro Kunisada,Takumi Era,T. Sakakura +7 more
TL;DR: In this paper, the authors used a monoclonal anti-c-kit antibody, ACK2, as an antagonistic blocker of c-kit function to interfere with the development of melanocytes during embryonic and postnatal life.
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Enrichment and characterization of murine hematopoietic stem cells that express c-kit molecule
Seiji Okada,Hiromitsu Nakauchi,Kazunari Nagayoshi,Shin Ichi Nishikawa,Yasusada Miura,Toshio Suda +5 more
TL;DR: The data show that the c- kit molecule is expressed in primitive stem cells and plays an essential role in the early stages of hematopoiesis.
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Exon skipping by mutation of an authentic splice site of c-kit gene in W/W mouse
TL;DR: Mutation in W homozygous mouse was identified as a single base substitution at the 5'-splice donor site of the exon which encodes the transmembrane domain which should provide the genetic base for not only the receptor function but the splicing mechanism.