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Shinjiro Hamano
Researcher at Nagasaki University
Publications - 126
Citations - 5212
Shinjiro Hamano is an academic researcher from Nagasaki University. The author has contributed to research in topics: Immune system & Cytokine. The author has an hindex of 32, co-authored 115 publications receiving 4788 citations. Previous affiliations of Shinjiro Hamano include University of Virginia & Kyushu University.
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Journal ArticleDOI
Cutting Edge: Role of IL-27/WSX-1 Signaling for Induction of T-Bet Through Activation of STAT1 During Initial Th1 Commitment
Atsunobu Takeda,Shinjiro Hamano,Atsushi Yamanaka,Toshikatsu Hanada,Tatsuro Ishibashi,Tak W. Mak,Akihiko Yoshimura,Hiroki Yoshida +7 more
TL;DR: The IL-27/WSX-1 signaling system plays a pivotal role by STAT1-mediated T-bet induction before the IL-12R system during the initiation of Th1 differentiation.
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WSX-1 Is Required for the Initiation of Th1 Responses and Resistance to L. major Infection
Hiroki Yoshida,Hiroki Yoshida,Hiroki Yoshida,Shinjiro Hamano,Giorgio Senaldi,Todd Covey,Raffaella Faggioni,Sharon X. Mu,Min Xia,Andrew Wakeham,Andrew Wakeham,Hiroshi Nishina,Hiroshi Nishina,Julia Potter,Julia Potter,Chris Saris,Tak W. Mak,Tak W. Mak +17 more
TL;DR: WSX-1 is essential for the initial mounting of Th1 responses but dispensable for their maintenance, and IFN-gamma production during the later phases of the infection was not impaired in the knockout.
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SOCS-3 regulates onset and maintenance of TH2-mediated allergic responses
Yoh Ichi Seki,Hiromasa Inoue,Naoko Nagata,Katsuhiko Hayashi,Satoru Fukuyama,Koichiro Matsumoto,Okiru Komine,Shinjiro Hamano,Kunisuke Himeno,Kyoko Inagaki-Ohara,Nicholas A. Cacalano,Anne O'Garra,Tadahilo Oshida,Hirohisa Saito,James A. Johnston,Akihiko Yoshimura,Masato Kubo +16 more
TL;DR: It is suggested that SOCS-3 has an important role in regulating the onset and maintenance of TH2-mediated allergic immune disease, and may be a new therapeutic target for the development of antiallergic drugs.
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Infiltration of COX-2–expressing macrophages is a prerequisite for IL-1β–induced neovascularization and tumor growth
Shintaro Nakao,Takashi Kuwano,Chikako Tsutsumi-Miyahara,Shu Ichi Ueda,Yusuke N. Kimura,Yusuke N. Kimura,Shinjiro Hamano,Koh Hei Sonoda,Yasuo Saijo,Toshihiro Nukiwa,Robert M. Strieter,Tatsuro Ishibashi,Michihiko Kuwano,Michihiko Kuwano,Mayumi Ono +14 more
TL;DR: Macrophage involvement might be a prerequisite for IL-1 beta-induced neovascularization and tumor progression, and a COX-2 inhibitor reduced tumor growth, angiogenesis, and macrophage infiltration in LLC/IL-1beta.
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WSX-1 Is Required for Resistance to Trypanosoma cruzi Infection by Regulation of Proinflammatory Cytokine Production
Shinjiro Hamano,Kunisuke Himeno,Yoshiyuki Miyazaki,Yoshiyuki Miyazaki,Kazunari Ishii,Atsushi Yamanaka,Atsushi Yamanaka,Atsunobu Takeda,Manxin Zhang,Hajime Hisaeda,Tak W. Mak,Akihiko Yoshimura,Hiroki Yoshida,Hiroki Yoshida +13 more
TL;DR: During T. cruzi infection, WSX-1 suppresses liver injury by regulating production of proinflammatory cytokines, while controlling parasitemia by suppression of Th2 responses, demonstrating its novel role as an inhibitory regulator of cytokine production.