Julia Potter

TL;DR: Comparison of the requirement for Casp9 and Casp3 in different apoptotic settings indicates the existence of at least four different apoptosis pathways in mammalian cells.

TL;DR: It is reported here that mice bearing a disruption in the NF-ATc gene fail to develop normal cardiac valves and septa and die of circulatory failure before day 14.5 of development, indicating that the Ca2+/calcineurin/NF-atc signalling pathway is essential for normal cardiac valve and septum morphogenesis and hence, NF- ATc and its regulatory pathways are candidates for genetic defects underlying congenital human heart disease.

TL;DR: The death of Brca1(5-6) mutant embryos prior to gastrulation may be due to a failure of the proliferative burst required for the development of the different germ layers, and the fact that mutant blastocyst growth is grossly impaired in vitro.

TL;DR: A profound reduction of TCR alpha beta+CD4-CD8+ T cells in IRF-1-deficient mice, with a thymocyte developmental defect, reveals a critical role for IRF -1 in T cell development.

TL;DR: Lymphocyte-specific interferon regulatory factor (LSIRF) (now called IRF4) is a transcription factor expressed only in lymphocytes that is essential for the function and homeostasis of both mature B and mature T lymphocytes.