Tomohiko Wakayama

TL;DR: It is reported that irreparable DNA damage, as caused by ionizing radiation, abrogates renewal of MSCs in mice, and deficiency of Ataxia-telangiectasia mutated (ATM), a central transducer kinase of the DNA-damage response, sensitizes MSC's to ectopic differentiation, demonstrating that the kinase protects MSCS from their premature differentiation by functioning as a "stemness checkpoint" to maintain the stem cell quality and quantity

TL;DR: Endothelial PI3K-C2α deficiency in vivo suppressed postischemic and tumor angiogenesis and diminished vascular barrier function with a greatly augmented susceptibility to anaphylaxis and a higher incidence of dissecting aortic aneurysm formation in response to angiotensin II infusion.

TL;DR: It is indicated that OCTN1 plays a pivotal role for maintenance of systemic and intestinal exposure of ergothioneine, which could be important for protective effects against intestinal tissue injuries, providing a possible diagnostic tool to distinguish the inflammatory bowel diseases.

TL;DR: Results suggested that SgIGSF occurs in the plasma membrane of spermatogenic cells during the earlier stages of sPermatogenesis, and is cloned and characterized as a novel immunoglobulin superfamily gene from the cDNA library of adult mouse testis.

TL;DR: Findings indicate that OCTN2 is predominantly responsible for the uptake of carnitine from the apical surface of mouse small intestinal epithelial cells, and it may therefore be a promising target for oral delivery of therapeutic agents that are OCTn2 substrates.