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Shizhu Chen
Researcher at Chinese Academy of Sciences
Publications - 46
Citations - 2939
Shizhu Chen is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Drug delivery & Drug carrier. The author has an hindex of 22, co-authored 45 publications receiving 1778 citations. Previous affiliations of Shizhu Chen include Center for Excellence in Education & Hebei University.
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Journal ArticleDOI
Carbon-dot-supported atomically dispersed gold as a mitochondrial oxidative stress amplifier for cancer treatment.
Ningqiang Gong,Ningqiang Gong,Xiaowei Ma,Xiaoxia Ye,Qunfang Zhou,Xiao’ai Chen,Xiaoli Tan,Shengkun Yao,Shuaidong Huo,Tingbin Zhang,Shizhu Chen,Shizhu Chen,Xucong Teng,Xixue Hu,Jie Yu,Yaling Gan,Huaidong Jiang,Jinghong Li,Xing-Jie Liang +18 more
TL;DR: It is demonstrated that MitoCAT-g amplifies the oxidative stress in mitochondria and suppresses tumour growth in vivo, representing a promising agent for anticancer applications.
Journal ArticleDOI
Comprehensive understanding of magnetic hyperthermia for improving antitumor therapeutic efficacy.
Xiao-Li Liu,Xiao-Li Liu,Yifan Zhang,Yanyun Wang,Wenjing Zhu,Galong Li,Xiaowei Ma,Yihan Zhang,Shizhu Chen,Shivani Tiwari,Kejian Shi,Shouwen Zhang,Haiming Fan,Yong Xiang Zhao,Xing-Jie Liang +14 more
TL;DR: A comprehensive understanding of MH for improving antitumor therapeutic efficacy is provided, which would be of utmost benefit towards guiding the users and for the future development of MNPs-MH towards successful application in medicine.
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Self-Supply of O 2 and H 2 O 2 by a Nanocatalytic Medicine to Enhance Combined Chemo/Chemodynamic Therapy.
Shutao Gao,Shutao Gao,Yan Jin,Kun Ge,Zhenhua Li,Huifang Liu,Xinyue Dai,Yinghua Zhang,Shizhu Chen,Xing-Jie Liang,Jinchao Zhang +10 more
TL;DR: The construction of a nanocatalytic medicine, CaO2@DOX@ZIF‐67, via a bottom‐up approach, that simultaneously supplies O2 and H2O2 to achieve improved chemo/chemodynamic therapy.
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Near-Infrared Emission CuInS/ZnS Quantum Dots: All-in-One Theranostic Nanomedicines with Intrinsic Fluorescence/Photoacoustic Imaging for Tumor Phototherapy
Guoxian Lv,Guoxian Lv,Weisheng Guo,Wei Zhang,Tingbin Zhang,Shuyi Li,Shizhu Chen,Ahmed Shaker Eltahan,Dongliang Wang,Y G Wang,Jinchao Zhang,Paul C. Wang,Jin Chang,Xing-Jie Liang +13 more
TL;DR: The use of CuInS/ZnS quantum dots (ZCIS QDs) as "all-in-one" versatile nanomedicines that possess intrinsic imaging and therapeutic capabilities within a well-defined nanostructure allow high therapeutic efficacy as well as noninvasively monitoring tumor site localization profiles by imaging techniques and thus hold great potential as precision theranostic nanomedICines.
Journal ArticleDOI
Hybrid Mesoporous Silica-Based Drug Carrier Nanostructures with Improved Degradability by Hydroxyapatite
Xiaohong Hao,Xixue Hu,Cuimiao Zhang,Shizhu Chen,Zhenhua Li,Xinjian Yang,Huifang Liu,Guang Jia,Dandan Liu,Kun Ge,Xing-Jie Liang,Jinchao Zhang +11 more
TL;DR: The biological experiment results show that the mesoporous silica nanoparticles/hydroxyapatite (MSNs/HAP) hybrid drug carrier not only exhibits good biocompatibility and antitumor effect but also greatly reduces the side effects of free DOX.