Showing papers by "Sho Yamasaki published in 2008"
TL;DR: The results suggest that Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue.
Abstract: Macrophage-inducible C-type lectin (Mincle) is expressed mainly in macrophages and is induced after exposure to various stimuli and stresses. Here we show that Mincle selectively associated with the Fc receptor common gamma-chain and activated macrophages to produce inflammatory cytokines and chemokines. Mincle-expressing cells were activated in the presence of dead cells, and we identified SAP130, a component of small nuclear ribonucloprotein, as a Mincle ligand that is released from dead cells. To investigate whether Mincle is required for normal responses to cell death in vivo, we induced thymocyte death by irradiating mice and found that transient infiltration of neutrophils into the thymus could be blocked by injection of Mincle-specific antibody. Our results suggest that Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue.
611 citations
TL;DR: The swift IL-17 response mounted by antigen-naive gammadelta T cells suggests a critical role for these cells at the onset of an acute inflammatory response to novel antigens, and thymic selection determines the effector fate of gammad delta T cells rather than constrains their antigen specificities.
440 citations
TL;DR: It is demonstrated that the lysosomal protein LAPTM5 negatively regulated surface TCR expression by specifically interacting with the invariant signal-transducing CD3zeta chain and promoting its degradation without affecting other CD3 proteins,CD3epsilon, CD3delta, or CD3gamma.
62 citations
TL;DR: In this paper, the thermal conductivity of nuclear fuels such as UO2+x and (U,Pu)O2−x has been calculated by the molecular dynamics (MD) simulation in terms of oxygen stoichiometric parameter x, temperature and Pu content.
18 citations
TL;DR: FcRgamma-mediated sustained Erk activation is critical for IgE-induced mast cell survival through autocrine production of IL-3 and Transmembrane adaptors LAT and NTAL contribute to the maintenance of prolonged Erkactivation through membrane retention of the Ras-activating complex, Grb2-Sos.
16 citations
TL;DR: Gads is a Grb2-like adaptor protein expressed in hematopoietic cells and has been shown to suppress the IgE-mediated allergic reaction with minimum adverse effects on both innate and acquired immune responses.
Abstract: Gads is a Grb2-like adaptor protein expressed in hematopoietic cells. We demonstrated that mast cells from Gads 2/2 mice have selective functional defects. Bone marrow-derived mast cells from Gads 2/2 mice failed to induce Ca 21 mobilization, degranulation and cytokine production upon crosslinking of FceRI. In vivo passive cutaneous anaphylaxis was also greatly impaired in Gads 2/2 mice. In contrast, Gads was dispensable for Toll-like receptor-mediated cytokine production in mast cells. Accordingly, mast cell-dependent resistance to acute peritoneal bacterial infection is not reduced in Gads 2/2 mice in vivo. Moreover, mature T and B cell responses and antibody production upon immunization were apparently normal in Gads 2/2 mice. Thus, inhibition of Gads in vivo would suppress the IgE-mediated allergic reaction with minimum adverse effects on both innate and acquired immune responses, and Gads could be an ideal target for the control of allergic responses.
15 citations
TL;DR: The results suggest that endogenous Rap GTPases downstream of pre-TCR play an essential role in rescuing pre-T cells from the p53-mediated checkpoint response, thus allowing Notch-mediated expansion and differentiation.
14 citations