H
Hiromitsu Hara
Researcher at Kagoshima University
Publications - 85
Citations - 5907
Hiromitsu Hara is an academic researcher from Kagoshima University. The author has contributed to research in topics: Cytokine & Immune system. The author has an hindex of 36, co-authored 83 publications receiving 5378 citations. Previous affiliations of Hiromitsu Hara include Austrian Academy of Sciences & Saga University.
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Journal ArticleDOI
Mincle is an ITAM-coupled activating receptor that senses damaged cells.
TL;DR: The results suggest that Mincle is a receptor that senses nonhomeostatic cell death and thereby induces the production of inflammatory cytokines to drive the infiltration of neutrophils into damaged tissue.
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Resident Vδ1+ γδ T Cells Control Early Infiltration of Neutrophils after Escherichia coli Infection via IL-17 Production
TL;DR: A novel role of γδ T cells as a first line of host defense controlling neutrophil-mediated innate immune responses is demonstrated, which is generally regarded as a part of early induced immune responses, which bridge innate and adaptive immune responses.
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Essential Role of IL-17A in the Formation of a Mycobacterial Infection-Induced Granuloma in the Lung
Yuko Okamoto Yoshida,Masayuki Umemura,Ayano Yahagi,Rebecca L. O'Brien,Koichi Ikuta,Kenji Kishihara,Hiromitsu Hara,Susumu Nakae,Yoichiro Iwakura,Goro Matsuzaki +9 more
TL;DR: IL-17A produced by TCR γδ T cells plays a critical role in the prevention of M. tuberculosis infection through the induction of mature granuloma formation.
Journal ArticleDOI
The MAGUK family protein CARD11 is essential for lymphocyte activation.
Hiromitsu Hara,Teiji Wada,Teiji Wada,Chris Bakal,Ivona Kozieradzki,Ivona Kozieradzki,Shinobu Suzuki,Nobutaka Suzuki,Mai Nghiem,Mai Nghiem,Emily K. Griffiths,Emily K. Griffiths,Connie M. Krawczyk,Connie M. Krawczyk,Birgit Bauer,Fulvio D'Acquisto,Sankar Ghosh,Wen Chen Yeh,Gottfried Baier,Robert Rottapel,Josef M. Penninger,Josef M. Penninger +21 more
TL;DR: The results show that the same family of molecules are critical regulators of neuronal synapses and immune receptor signaling.
Journal ArticleDOI
The adaptor protein CARD9 is essential for the activation of myeloid cells through ITAM-associated and Toll-like receptors.
Hiromitsu Hara,Chitose Ishihara,Arata Takeuchi,Takayuki Imanishi,Liquan Xue,Stephan W. Morris,Masanori Inui,Toshiyuki Takai,Akira Shibuya,Shinobu Saijo,Yoichiro Iwakura,Naohito Ohno,Haruhiko Koseki,Hiroki Yoshida,Josef M. Penninger,Takashi Saito +15 more
TL;DR: Deletion of the gene encoding the Bcl-10 adaptor–binding partner CARD9 resulted in impaired myeloid cell activation of NF-κB signaling by several ITAM-associated receptors, and CARD9 was required for Toll-like receptor–induced activation of dendritic cells through the activation of mitogen-activated protein kinases.