S
Shuling Guo
Researcher at Duke University
Publications - 7
Citations - 1608
Shuling Guo is an academic researcher from Duke University. The author has contributed to research in topics: Inositol & Actin. The author has an hindex of 7, co-authored 7 publications receiving 1558 citations. Previous affiliations of Shuling Guo include University of California, Los Angeles & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Phosphatidylinositol 4,5-Bisphosphate Functions as a Second Messenger that Regulates Cytoskeleton–Plasma Membrane Adhesion
Drazen Raucher,Thomas P. Stauffer,Wen Chen,Kang Shen,Shuling Guo,John D. York,Michael P. Sheetz,Tobias Meyer +7 more
TL;DR: This study suggests that plasma membrane PIP2 controls dynamic membrane functions and cell shape by locally increasing and decreasing the adhesion between the actin-based cortical cytoskeleton and the plasma membrane.
Journal ArticleDOI
Sac1-like domains of yeast sac1, inp52, and inp53 and of human synaptojanin encode polyphosphoinositide phosphatases
TL;DR: It is demonstrated that PPIPase activity is a key regulator of membrane trafficking and actin cytoskeleton organization and suggest signaling roles for phosphoinositides other than PI 4,5-bisphosphate in these processes.
Journal ArticleDOI
Pleiotropic Alterations in Lipid Metabolism in Yeast sac1 Mutants: Relationship to “Bypass Sec14p” and Inositol Auxotrophy
Marcos P. Rivas,Brian G. Kearns,Zhigang Xie,Shuling Guo,M. Chandra Sekar,Kohei Hosaka,Satoshi Kagiwada,John D. York,Vytas A. Bankaitis +8 more
TL;DR: It is demonstrated that accumulation of phosphatidylinositol-4-phosphate in sac1 mutants is insufficient to effect bypassSec14p, and a model in which phospholipase D activity contributes to generation of DAG that, in turn, effects bypass Sec14p is supported.
Journal ArticleDOI
A new link between the c-Abl tyrosine kinase and phosphoinositide signalling through PLC-γ1
Rina Plattner,Brenda J. Irvin,Brenda J. Irvin,Shuling Guo,Shuling Guo,Kevin Blackburn,Andrius Kazlauskas,Robert T. Abraham,Robert T. Abraham,John D. York,John D. York,Ann Marie Pendergast +11 more
TL;DR: It is shown that functional phospholipase C-γ1 (PLC-γ 1) is required for c-Abl activation by PDGFR, uncovering a newly discovered functional interdependence between non-receptor Tyr kinase and lipid signalling pathways.
Journal ArticleDOI
Specificity determinants in phosphoinositide dephosphorylation: crystal structure of an archetypal inositol polyphosphate 5-phosphatase
TL;DR: Based on the structure of the inositol polyphosphate 5-phosphatase domain of SPsynaptojanin, a series of mutants are described that exhibit altered substrate specificity providing general determinants for substrate recognition.